Zebrafish as experimental model to establish the contribution of mutant p53 and ID4 to breast cancer angiogenesis in vivo

We appreciate the interest and the editorial comments of Luo J and Fan S on our article “The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1”, recently published in EMBO Reports (1). We agree with the first criticism raised by the authors. Indeed, the use of in vivo tumor experimental systems would strongly strengthen the relevance of the results presented in our study and would clarify the extent of the contribution of the ribonucleoprotein complex comprising mutant p53, ID4, SRSF1 proteins and lncRNA MALAT1 to the modulation of VEGFA isoforms and to tumor angiogenesis.