Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors Academic Article uri icon

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abstract

  • BACKGROUND: Risk factors for pediatric stroke are poorly understood and require study to improve prevention. Total cholesterol and triglyceride values peak to near-adult levels before puberty, a period of increased stroke incidence. The role of lipids in childhood arterial ischemic stroke has been minimally investigated. METHODS: We performed a cross-sectional analysis of lipid and Lp(a) concentrations in children with arterial ischemic stroke in the International Pediatric Stroke Study to compare the prevalence of dyslipidemia and high- or low-ranking lipid values in our dataset with reported population values. We analyzed sex, body mass index, race, ethnicity, family history, and stroke risk factors for associations with dyslipidemia, high non-high-density lipoprotein cholesterol, and hypertriglyceridemia. RESULTS: Compared with the National Health and Nutrition Examination Survey, a higher proportion of children ≥5 years with arterial ischemic stroke had dyslipidemia (38.4% versus 21%), high total cholesterol (10.6% versus 7.4%), high non-high-density lipoprotein cholesterol (23.1% versus 8.4%), and low high-density lipoprotein cholesterol (39.8% versus 13.4%). The lipid values that corresponded to one standard deviation above the mean (84th percentile) in multiple published national studies generally corresponded to a lower ranking percentile in children aged five years or older with arterial ischemic stroke. Dyslipidemia was more likely associated with an underweight, overweight, or obese body mass index compared with a healthy weight. Ethnic background and an acute systemic illness were also associated with abnormal lipids. CONCLUSIONS: Dyslipidemia and hypertriglyceridemia may be more prevalent in children with arterial ischemic stroke compared with stroke-free children.

authors

  • Sultan, Sally
  • Dowling, Michael
  • Kirton, Adam
  • DeVeber, Gabrielle
  • Linds, Alexandra
  • Elkind, Mitchell SV
  • Bernard, Tim
  • Dowling, Michael
  • Hernandez, Marta
  • Rivkin, Michael
  • Kopyta, Ilona
  • Ichord, Rebecca
  • Benedict, Susan
  • Mackay, Mark
  • Kirton, Adam
  • Zafeiriou, Dimitrios
  • Troncoso, Monica
  • Yager, Jerome
  • Abraham, Lisa
  • Lo, Warren
  • Gonzalez, Veronica
  • Saengpattrachai, Montri
  • Chan, Anthony
  • Abdallah, Abdallah
  • Brankovic-Sreckovic, Vesna
  • Kolk, Anneli
  • Carpenter, Jessica
  • Kovacevic, Gordana
  • Amlie-Lefond, Catherine
  • Steinlin, Maja
  • Paolicchi, Juliann
  • Carell, Monroe
  • Bjornson, Bruce
  • Kosofsky, Barry
  • Wong, Virginia
  • Pergami, Paola
  • Friedman, Neil
  • Guang, Yang
  • Humphreys, Peter
  • Nowak-Göttl, Ulrike
  • Ferriero, Donna
  • Xavier, Frederico
  • Fryer, Robert
  • Andrade Alveal, Lucila
  • Altuna, Diana
  • Felling, Ryan
  • Pavlakis, Steven
  • Grabowski, Eric
  • Golomb, Meredith
  • Noetzel, Michael
  • Khoury, Chaouki
  • Lerner, Norma
  • Blair, Amanda
  • Rafay, Mubeen

publication date

  • January 2018