Journal article
Sharing some interim data in trial monitoring can mislead or unmask trial investigators: A scenario-based survey of trial experts
Abstract
BACKGROUND: Sharing masked interim results by the Data Safety Monitoring Board (DSMB) with non-DSMB members is an important issue that can affect trial integrity. Our survey's objective is to collect evidence to understand how seemingly masked interim results or result extrapolations are interpreted and discuss whether these results should be shared at interim.
METHODS: Conducted a 6 scenario-question survey asking trial experts how they …
Authors
Debono VB; Mbuagbaw L; Paul J; Buckley N; Thabane L
Journal
Contemporary Clinical Trials Communications, Vol. 7, , pp. 81–85
Publisher
Elsevier
Publication Date
September 2017
DOI
10.1016/j.conctc.2017.05.005
ISSN
2451-8654