Ontogenic development of dopamine D4 receptor in rat brain Journal Articles

abstract

• The postnatal development of rat brain dopamine D4 receptor gene expression was studied in animals 1 day to 1 year old, using the polymerase chain reaction technique. The level of expression of the D4 mRNA was appreciable at birth (day 1), increased to maximum at day 3, and showed declines at day 28. D4 mRNA expression remained unchanged at the ages of 6 months to 1 year. The mRNA expression at day 1 is about 50% of that observed on day 3, and declines approximately 50% by day 28. In contrast, the dopamine D2 mRNA expression was maximum at day 28, which is consistent with the reported studies.

authors

• Nair, Venugopalan D
• Mishra, Ram

status

• published 

publication date

• December 1995

has subject area

• 1109 Neurosciences (FoR)
• 1701 Psychology (FoR)
• 1702 Cognitive Sciences (FoR)
• Animals (MeSH)
• Animals, Newborn (MeSH)
• Base Sequence (MeSH)
• Brain (MeSH)
• Gene Expression Regulation, Developmental (MeSH)
• Molecular Sequence Data (MeSH)
• Neurology & Neurosurgery (Science Metrix)
• Polymerase Chain Reaction (MeSH)
• RNA, Messenger (MeSH)
• Rats (MeSH)
• Rats, Sprague-Dawley (MeSH)
• Receptors, Dopamine D2 (MeSH)
• Receptors, Dopamine D4 (MeSH)

published in

• Brain Research  Journal

keywords

• Animals
• Animals, Newborn
• Base Sequence
• Brain
• Gene Expression Regulation, Developmental
• Molecular Sequence Data
• Polymerase Chain Reaction
• RNA, Messenger
• Rats
• Rats, Sprague-Dawley
• Receptors, Dopamine D2
• Receptors, Dopamine D4

Digital Object Identifier (DOI)

• 10.1016/0165-3806(96)83499-7

PubMed ID

• 8719342

start page

• 180

end page

• 183

volume

• 90

issue

• 1-2