New Tuberculosis Vaccine Strategies: Taking Aim at Un-Natural Immunity Journal Articles

abstract

• Despite some major progress made in developing tuberculosis (TB) vaccine strategies, with a dozen novel vaccines currently in the clinical pipeline, the world is still missing an effective TB vaccine. This questions whether any major breakthroughs can be achieved without making a drastic departure from the current strategy, which creates a state of 'near-natural immunity', imitating the natural immunity developed after Mycobacterium tuberculosis (Mtb) infection. Here, we argue instead that mounting evidence suggests an effective strategy ought to induce a state of all-around 'un-natural' immunity comprising trained innate immunity (TII), tissue-resident memory T cells (TRM), and anti-Mtb surface antibodies in the lung. Thus, here we summarize the latest information, thinking, and development in the field of TB and vaccines.

authors

• Jeyanathan, Mangalakumari
• Yao, Yushi
• Afkhami, Sam
• Smaill, Fiona
• Xing, Zhou

status

• published 

publication date

• May 2018

has subject area

• 1107 Immunology (FoR)
• Animals (MeSH)
• Humans (MeSH)
• Immunity, Innate (MeSH)
• Immunologic Memory (MeSH)
• Immunology (Science Metrix)
• Mycobacterium tuberculosis (MeSH)
• T-Lymphocytes (MeSH)
• Tuberculosis (MeSH)
• Tuberculosis Vaccines (MeSH)

published in

• Trends in Immunology  Journal

keywords

• Animals
• Humans
• Immunity, Innate
• Immunologic Memory
• Mycobacterium tuberculosis
• T-Lymphocytes
• Tuberculosis
• Tuberculosis Vaccines

Digital Object Identifier (DOI)

• 10.1016/j.it.2018.01.006

PubMed ID

• 29429859

start page

• 419

end page

• 433

volume

• 39

issue

• 5