Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa Academic Article uri icon

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abstract

  • Key Points Andexanet reversed apixaban anticoagulation in healthy volunteers within minutes after administration and for the duration of infusion. Andexanet was generally well tolerated, with no evidence of prothrombotic activity in preclinical models and in healthy subjects.

authors

  • Siegal, Deborah
  • Lu, Genmin
  • Leeds, Janet M
  • Karbarz, Mark
  • Castillo, Janice
  • Mathur, Vandana
  • Hutchaleelaha, Athiwat
  • Sinha, Uma
  • Kitt, Michael
  • McClure, Matt
  • Hollenbach, Stanley J
  • Curnutte, John T
  • Conley, Pamela B
  • Crowther, Mark

publication date

  • September 26, 2017