Pooled analysis of higher versus lower blood pressure targets for vasopressor therapy septic and vasodilatory shock

PurposeGuidelines for shock recommend mean arterial pressure (MAP) targets for vasopressor therapy of at least 65 mmHg and, until recently, suggested that patients with underlying chronic hypertension and atherosclerosis may benefit from higher targets. We conducted an individual patient-data meta-analysis of recent trials to determine if patient variables modify the effect of different MAP targets.MethodsWe searched the MEDLINE, EMBASE, and …