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MicroRNA-128-3p-mediated depletion of Drosha...
Journal article

MicroRNA-128-3p-mediated depletion of Drosha promotes lung cancer cell migration

Abstract

Alteration in microRNAs (miRNAs) expression is a frequent finding in human cancers. In particular, widespread miRNAs down-regulation is a hallmark of malignant transformation. In the present report, we showed that the miR-128-3p, which is up-regulated in lung cancer tissues, has Drosha and Dicer, two key enzymes of miRNAs processing, as the main modulation targets leading to the widespread down-regulation of miRNA expression. We observed that …

Authors

Frixa T; Sacconi A; Cioce M; Roscilli G; Ferrara FF; Aurisicchio L; Pulito C; Telera S; Carosi M; Muti P

Journal

Carcinogenesis, Vol. 39, No. 2, pp. 293–304

Publisher

Oxford University Press (OUP)

Publication Date

February 9, 2018

DOI

10.1093/carcin/bgx134

ISSN

0143-3334