Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry Academic Article uri icon

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abstract

  • Delay discounting (DD), the tendency to discount the value of delayed versus current rewards, is elevated in a constellation of diseases and behavioral conditions. We performed a genome-wide association study of DD using 23,127 research participants of European ancestry. The most significantly associated single-nucleotide polymorphism was rs6528024 (P = 2.40 × 10-8), which is located in an intron of the gene GPM6B. We also showed that 12% of the variance in DD was accounted for by genotype and that the genetic signature of DD overlapped with attention-deficit/hyperactivity disorder, schizophrenia, major depression, smoking, personality, cognition and body weight.

authors

  • Sanchez-Roige, Sandra
  • Fontanillas, Pierre
  • Elson, Sarah L
  • Pandit, Anita
  • Schmidt, Ellen M
  • Foerster, Johanna R
  • Abecasis, Gonçalo R
  • Gray, Joshua C
  • de Wit, Harriet
  • Davis, Lea K
  • MacKillop, James
  • Palmer, Abraham A

publication date

  • January 2018