Very high rate of misdiagnosis of celiac disease in clinical practice. Journal Articles uri icon

  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All


  • OBJECTIVE: We evaluated the accuracy of the diagnosis of celiac disease (CD) performed in the community clinical setting compared with that of an academic experienced center. MATERIALS: Original biopsy slides and reports used for diagnosis in the community setting and the CD serology were revised in 70 consecutive patients attending our institution for a second opinion. An expert team determined the final diagnosis unaware of the original consideration. RESULTS: The poor quality of samples made histology assessment by the expert pathologist uncertain in 8.7% of slides with CD external diagnosis. We detected a divergent diagnosis between the two practice settings in 46.3% of available cases with a significant overdiagnosis of CD in the community (p < 0.0001). Congruent serology results were demonstrated in 72.2% of cases. CONCLUSION: Our study detected a high rate of histopathological and serological misdiagnosis of CD in community practice which may have profound negative impact on patients.


  • Pinto-Sanchez, Maria
  • Smecuol, Edgardo
  • Vázquez, Horacio
  • Mazure, Roberto
  • Mauriño, Eduardo
  • Bai, Julio César

publication date

  • December 2009