Rewiring metabolism under oxygen deprivation

Naked mole-rats evolved a means to cope with anoxia When faced with a reduced availability of oxygen in the environment (hypoxia), vertebrates can make a variety of respiratory, cardiovascular, and hematological adjustments to ensure an uninterrupted supply of oxygen to the cells of metabolizing tissues ( 1 , 2 ). These are adaptive solutions for “aerobic organisms in an aerobic world” ( 3 ). Coping with the complete absence of oxygen (anoxia) …