Journal article
Inhibition of Exercise-Induced Bronchoconstriction by MK-571, a Potent Leukotriene D4–Receptor Antagonist
Abstract
BACKGROUND: Exercise is a common stimulus of bronchoconstriction in subjects with asthma, who also have bronchoconstriction after inhaling the sulfidopeptide leukotriene D4 (LTD4). The purpose of this study was to investigate the importance of LTD4 as a mediator of exercise-induced bronchoconstriction.
METHODS: In a double-blind, randomized, crossover study, 12 subjects with stable asthma were treated intravenously with MK-571 (160 mg), a …
Authors
Manning PJ; Watson RM; Margolskee DJ; Williams VC; Schwartz JI; O'Byrne PM
Journal
The New England Journal of Medicine, Vol. 323, No. 25, pp. 1736–1739
Publisher
Massachusetts Medical Society
Publication Date
December 20, 1990
DOI
10.1056/nejm199012203232504
ISSN
0028-4793