Iron Status in Pediatric Celiac Disease Journal Articles

abstract

• ABSTRACTThe present study assessed the role of serum ferritin as a noninvasive biomarker in the diagnosis and monitoring of pediatric celiac disease. A retrospective chart review was performed on patients younger than 18 years old at time of diagnosis (n = 193) between 1998 and 2015. A total of 653 paired values demonstrated a weak negative correlation between serum ferritin and tissue transglutaminase‐immunoglobulin A (r = −0.114; P = 0.004), necessitating further evaluation. A significant relationship was found between reduction of tissue transglutaminase‐immunoglobulin A and increase in serum ferritin after institution of a gluten‐free diet (P < 0.0001), suggesting that resolution of villous damage is necessary for promoting adequate iron absorption.

authors

• Popov, Jelena
• Baldawi, Mina
• Mbuagbaw, Lawrence
• Gould, Michelle
• Mileski, Heather
• Brill, Herbert
• Pai, Nikhil

status

• published 

publication date

• April 2018

has subject area

• 11 Medical and Health Sciences (FoR)
• Adolescent (MeSH)
• Biomarkers (MeSH)
• Celiac Disease (MeSH)
• Child (MeSH)
• Child, Preschool (MeSH)
• Female (MeSH)
• Ferritins (MeSH)
• Gastroenterology & Hepatology (Science Metrix)
• Humans (MeSH)
• Immunoglobulin A (MeSH)
• Iron (MeSH)
• Male (MeSH)
• Retrospective Studies (MeSH)
• Transglutaminases (MeSH)

published in

• Journal of Pediatric Gastroenterology and Nutrition  Journal

keywords

• Adolescent
• Biomarkers
• Celiac Disease
• Child
• Child, Preschool
• Female
• Ferritins
• Humans
• Immunoglobulin A
• Iron
• Male
• Retrospective Studies
• Transglutaminases

Digital Object Identifier (DOI)

• 10.1097/mpg.0000000000001761

PubMed ID

• 28953524

start page

• 651

end page

• 653

volume

• 66

issue

• 4