Journal article
Selective loss of early suppression in the dentate gyrus precedes kainic acid induced electrographic seizures
Abstract
The role of inhibitory and facilitatory processes in the induction of seizures was studied in a kainic acid (KA) model of epilepsy. The dentate gyrus (DG) response to paired-pulse stimulation of the perforant path (PP) was monitored prior to and immediately following the initial KA induced afterdischarge (AD) in rats chronically prepared with stimulation recording electrodes. The subjects received a 1-h program of stimulation consisting of …
Authors
Ikeda-Douglas CJ; Head E; Holsinger RMD; Tremblay L; Racine R; Milgram NW
Journal
Epilepsy Research, Vol. 31, No. 2, pp. 143–152
Publisher
Elsevier
Publication Date
July 1998
DOI
10.1016/s0920-1211(98)00028-x
ISSN
0920-1211