Journal article
The Influence of Anticodon–Codon Interactions and Modified Bases on Codon Usage Bias in Bacteria
Abstract
Most transfer RNAs (tRNAs) can translate more than one synonymous codon, and most codons can be translated by more than one isoacceptor tRNA. The rates of translation of synonymous codons are dependent on the concentrations of the tRNAs and on the rates of pairing of each anticodon-codon combination. Translational selection causes a significant bias in codon frequencies in highly expressed genes in most bacteria. By comparing codon frequencies …
Authors
Ran W; Higgs PG
Journal
Molecular Biology and Evolution, Vol. 27, No. 9, pp. 2129–2140
Publisher
Oxford University Press (OUP)
Publication Date
September 1, 2010
DOI
10.1093/molbev/msq102
ISSN
0737-4038