Further scientific issues in determining an occupational standard for cadmium

This contribution responds to the recent paper of Thun et al. (American Journal of Industrial Medicine 20:629-642, 1991) on an occupational standard for cadmium. The contribution of non-invasive in situ measurements of cadmium in liver and in kidney to the study of cadmium industrial toxicology is particularly reviewed. It is contended that clear scientific grounds do not exist for recommending cadmium in air occupational standard below 10 micrograms m-3, and that other arguments would need to be adduced to support a recommendation for a lower level. Last, a number of unanswered questions are identified and the need for further work is highlighted.