Absorption and distribution of estradiol from male seminal emissions during mating

Estradiol-17β (E₂) plays critical roles in female maturation, sexual receptivity, ovulation and fertility. In many mammals, contact with males can similarly affect these female parameters, whereas male excretions contain significant quantities of E₂ We administered radiolabeled estradiol ([³H]E₂) to male mice in doses representing a small fraction of their endogenous E₂ These males were paired with sexually receptive females, and radioactivity …