Journal article
A role for GPx3 in activity of normal and leukemia stem cells
Abstract
The determinants of normal and leukemic stem cell self-renewal remain poorly characterized. We report that expression of the reactive oxygen species (ROS) scavenger glutathione peroxidase 3 (GPx3) positively correlates with the frequency of leukemia stem cells (LSCs) in Hoxa9+Meis1-induced leukemias. Compared with a leukemia with a low frequency of LSCs, a leukemia with a high frequency of LSCs showed hypomethylation of the Gpx3 promoter …
Authors
Herault O; Hope KJ; Deneault E; Mayotte N; Chagraoui J; Wilhelm BT; Cellot S; Sauvageau M; Andrade-Navarro MA; Hébert J
Journal
Journal of Experimental Medicine, Vol. 209, No. 5, pp. 895–901
Publisher
Rockefeller University Press
Publication Date
May 7, 2012
DOI
10.1084/jem.20102386
ISSN
0022-1007
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBase SequenceBlotting, SouthernCell LineDNA-Binding ProteinsFlow CytometryFluorescenceGene Expression ProfilingGene Expression Regulation, NeoplasticGenetic VectorsGlutathione PeroxidaseHomeodomain ProteinsHumansLeukemiaMiceMicroscopy, ConfocalMolecular Sequence DataMyeloid Ecotropic Viral Integration Site 1 ProteinNeoplasm ProteinsNeoplastic Stem CellsReactive Oxygen SpeciesReal-Time Polymerase Chain ReactionSequence Analysis, DNAStem CellsTranscription Factors