Journal article
The biosynthesis of pramanicin in Stagonospora sp. ATCC 74235: a modified acyltetramic acid
Abstract
Biosynthetic incorporations of acetate, malonate and serine precursors which had been isotopically labelled with 2H, 13C, 15N and 18O into pramanicin 1 in Stagonospora sp. ATCC 74235 were demonstrated. Intact incorporation of a starter acetate and six extender malonates generates the acyclic, hydrophobic tail. A further intact acetate, in preference to malonate, and a serine entity which is incorporated only as the L-enantiomer and with the …
Authors
Harrison PHM; Duspara PA; Jenkins SI; Kassam SA; Liscombe DK; Hughes DW
Journal
Journal of the Chemical Society Perkin Transactions 1, Vol. 0, No. 24, pp. 4390–4402
Publisher
Royal Society of Chemistry (RSC)
Publication Date
2000
DOI
10.1039/b006007k
ISSN
1472-7781