Journal article
Pramanicin, an antifungal agent, raises cytosolic Ca2+ and causes cell death in vascular endothelial cells
Abstract
The effects of a newly discovered antifungal agent, pramanicin, on cytosolic Ca(2+) and cell viability of cultured bovine pulmonary artery endothelial cells and on endothelium-dependent relaxation of dog carotid arterial rings were investigated by digital dynamic fluorescence ratio imaging and morphological and contractility studies, respectively. Pramanicin 100 microM, previously shown to cause maximal endothelium-dependent and NO-mediated …
Authors
Kwan C-Y; Harrison PHM; Kwan TK
Journal
Vascular Pharmacology, Vol. 40, No. 1, pp. 35–42
Publisher
Elsevier
Publication Date
January 2003
DOI
10.1016/s1537-1891(02)00314-2
ISSN
1537-1891