Opposite Patterns of Synchrony in Sympatric Disease Metapopulations Journal Articles

abstract

• Measles epidemics in UK cities, which were regular and highly synchronous before vaccination, are known to have become irregular and spatially uncorrelated in the vaccine era. Whooping cough shows the reverse pattern, namely a shift from spatial incoherence and irregularity before vaccination to regular, synchronous epidemics afterward. Models show that these patterns can arise from disease-specific responses to dynamical noise. This analysis has implications for vaccination strategies and illustrates the power of comparative dynamical studies of sympatric metapopulations.

authors

• Rohani, Pejman
• Earn, David
• Grenfell, Bryan T

status

• published 

publication date

• October 29, 1999

has subject area

• Bordetella pertussis (MeSH)
• Demography (MeSH)
• Disease Outbreaks (MeSH)
• England (MeSH)
• Epidemiologic Methods (MeSH)
• General Science & Technology (Science Metrix)
• Humans (MeSH)
• Immunization Programs (MeSH)
• Incidence (MeSH)
• Measles (MeSH)
• Measles Vaccine (MeSH)
• Pertussis Vaccine (MeSH)
• Population Dynamics (MeSH)
• Stochastic Processes (MeSH)
• Wales (MeSH)
• Whooping Cough (MeSH)

published in

• Science  Journal

keywords

• Bordetella pertussis
• Demography
• Disease Outbreaks
• England
• Epidemiologic Methods
• Humans
• Immunization Programs
• Incidence
• Measles
• Measles Vaccine
• Pertussis Vaccine
• Population Dynamics
• Stochastic Processes
• Wales
• Whooping Cough

Digital Object Identifier (DOI)

• 10.1126/science.286.5441.968

PubMed ID

• 10542154

start page

• 968

end page

• 971

volume

• 286

issue

• 5441