Journal article
The ultrastructure of bone as revealed in electron microscopy of ion-milled sections
Abstract
Mineral makes up more than half the volume of bone, but its spatial and structural relationship to collagen and other proteins is still a matter of debate. Due to the nanometer-size of bone crystals this matter can be resolved only with transmission electron microscope (TEM) images. Using sections cut with an ultramicrotome, previous investigators determined most mineral lies in the 40nm wide gap zone in collagen fibrils. Using less invasive …
Authors
Schwarcz HP
Journal
Seminars in Cell and Developmental Biology, Vol. 46, , pp. 44–50
Publisher
Elsevier
Publication Date
October 2015
DOI
10.1016/j.semcdb.2015.06.008
ISSN
1084-9521