Gender differentials in commuting have been reported in the literature, often couched within the household responsibility hypothesis. This hypothesis attributes shorter commutes to females due to a disproportionate load of household responsibilities. The objective of the present study is to report research regarding commuting time in São Paulo Metropolitan Region, in Brazil. Based on microdata from the Demographic Census of 2010 the focus of the present study is on the role of marital status and presence of dependents on gender differentials in commuting time. Specifically, the research seeks to determine whether there is empirical support in this region for the household responsibility hypothesis. The results suggest that marital status exerts a stronger influence on the commuting time of working women, with the number of dependents (children and elderly) exerting a smaller influence on commuting time. Gender differentials are observed also for single and formerly married working females, which suggests other cultural or environmental factors not fully captured by the household responsibility hypothesis. Most studies, however, are set in North America. This research contributes towards the development of a broader, international knowledge foundation regarding gender and commuting patterns.