The Large Cytoplasmic Domain Is Not Required for Concentration of N-CAM at Cell-Cell Contacts in Transfected Mouse Neuroblastoma Cells Academic Article uri icon

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  • We examined the localization of the 140- and 180-kDa transmembrane isoforms of chicken N-CAM following transfection into mouse N2A neuroblastoma cells. Both isoforms were expressed at the cell surface and became partially or completely localized at areas of cell-cell contact after several days of culture or of in vitro differentiation. These results indicate that the presence of the large cytoplasmic domain of the 180-kDa N-CAM isoform is not necessary to bring about the localization of N-CAM to points of cell-cell contact.


  • Woo, Ming-ko
  • Kil, Sung-Hee
  • Adams, Lawrence D
  • Nguyen, Thanh N
  • Murray, Ben A

publication date

  • April 1993