PHOTOREPAIR OF NONADJACENT PYRIMIDINE DIMERS BY DNA PHOTOLYASE
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Photolyases reverse the harmful effects of UV light on cells by converting pyrimidine dimers (PyrPyr) into two pyrimidine monomers by utilizing near-UV and visible light. Previous work has shown that photolyase repairs T[c,s]T and T[t,s]T in DNA as well as UU in RNA, all of which are formed by joining the two adjacent pyrimidines in a light-dependent reaction. In this report, we show that PyrPyr formed in nonadjacent pyrimidines are also substrates for DNA photolyase.
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