Journal article
Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses
Abstract
BACKGROUND: Thymic stromal lymphopoietin (TSLP) is an epithelial-cell-derived cytokine that may be important in initiating allergic inflammation. AMG 157 is a human anti-TSLP monoclonal immunoglobulin G2λ that binds human TSLP and prevents receptor interaction.
METHODS: In this double-blind, placebo-controlled study, we randomly assigned 31 patients with mild allergic asthma to receive three monthly doses of AMG 157 (700 mg) or placebo …
Authors
Gauvreau GM; O'Byrne PM; Boulet L-P; Wang Y; Cockcroft D; Bigler J; FitzGerald JM; Boedigheimer M; Davis BE; Dias C
Journal
The New England Journal of Medicine, Vol. 370, No. 22, pp. 2102–2110
Publisher
Massachusetts Medical Society
Publication Date
May 29, 2014
DOI
10.1056/nejmoa1402895
ISSN
0028-4793