Journal article
Selective fluorination of m-tyrosine by OF2
Abstract
Fluorine-18 labeled aromatic amino acids are routinely used as tracers in positron emission tomography (PET) to study in vivo metabolic processes. The most versatile method for the production of such radiotracers is electrophilic fluorination of the aromatic amino acid with [18F]F2, which is most commonly produced by the gas-phase nuclear reaction 18O(p, n)18F. Although [18F]F2 is the major product, considerable amounts of [18F]OF2 (up to 20%) …
Authors
Azad BB; Ashique R; Chirakal R; Schrobilgen GJ
Journal
Journal of Fluorine Chemistry, Vol. 129, No. 1, pp. 22–27
Publisher
Elsevier
Publication Date
1 2008
DOI
10.1016/j.jfluchem.2007.08.004
ISSN
0022-1139