Journal article
Phospholipid synthesis: effects of solvents and catalysts on acylation
Abstract
The peptide dinitrophenylprolylthreoninamide (DNP-Pro-Thr-NH2) was used as a model system to develop better acylation conditions for the synthesis of phospholipids using catalyst-activated anhydrides. The acylation rate was found to be inversely related to the polarity of the solvent, chloroform alone resulting in much better rates of reaction than did pyridine, dimethylformamide (DMF) or mixtures of these solvents. Anhydride activated by …
Authors
Mangroo D; Gerber GE
Journal
Chemistry and Physics of Lipids, Vol. 48, No. 1-2, pp. 99–108
Publisher
Elsevier
Publication Date
6 1988
DOI
10.1016/0009-3084(88)90137-5
ISSN
0009-3084