Clonidine challenge test in Bulimia nervosa

Recent studies suggest that the α‐2 noradrenergic receptor may be of pathophysiologic importance in depression and possibly eating disorders. To assess this further, we administered 1.3 μ/kg i.v. clonidine to 14 bulimics and 11 controls and measured in blood GH, cortisol, MHPG, VMA, HVA, and cardiovascular responses pre‐ and postperturbation. There were no significant differences between groups in cardiovascular or endocrine responses except …