Functional characterization of the prostanoid DP...

Abstract

Spontaneous contractile activity of strips of human myometrium obtained from non-pregnant donors at the time of hysterectomy was inhibited by the selective prostanoid DP receptor agonists BW 245C (5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl)hydantoin) and ZK110841 ((5Z,13E)-(9R,11R,15S)-9 beta-chlor-15-cyclohexyl-11,15-dihydroxy-16,17,18,19, 20-pentanor-5,13-prostadienoic acid) with pEC50 values of 8.4 and 7.3 respectively but …

Authors

Fernandes B; Crankshaw D

Journal

European Journal of Pharmacology, Vol. 283, No. 1-3, pp. 73–81

Publisher

Elsevier

Publication Date

September 1995

DOI

10.1016/0014-2999(95)00288-v

ISSN

0014-2999

Associated Experts

Denis James Crankshaw

Professor Emeritus, Faculty of Health Sciences

Visit profile

Labels

Fields of Research (FoR)

3214 Pharmacology and pharmaceutical sciences 32 Biomedical and Clinical Sciences 3109 Zoology 5204 Cognitive and computational psychology 5205 Social and personality psychology

Medical Subject Headings (MeSH)

Adult Dinoprost Dose-Response Relationship, Drug Female Humans Hydantoins Hysterectomy Middle Aged Muscle Contraction Muscle, Smooth Myometrium Prostaglandin D2 Prostanoic Acids Receptors, Prostaglandin

Functional characterization of the prostanoid DP receptor in human myometrium