Journal article
Warfarin replacements: Mechanisms underlying emerging agents
Abstract
Warfarin is effective for the prevention and treatment of thromboembolic disorders. However, warfarin has a narrow therapeutic window, unpredictable pharmacology, and food and drug interactions that require regular monitoring and dose adjustment. Therefore, there is a clear need for new anticoagulants that can overcome these limitations. There are a number of potential targets for new anticoagulants within the coagulation cascade; factor Xa and …
Authors
Turpie AGG
Journal
Canadian Journal of Cardiology, Vol. 24, , pp. 56c–60c
Publisher
Elsevier
Publication Date
August 2008
DOI
10.1016/s0828-282x(08)71040-7
ISSN
0828-282X