Effect of temperature on the wetting behavior of hydroxypropyl methylcellulose in a twin-screw granulator

Temperature has rarely been examined in twin-screw wet granulation despite the obvious capabilities of the extruder for operating at elevated temperatures. The present work investigates the wetting behavior of a mixture of powders with different sorption characteristics at various temperatures to explain the unique granulation behavior witnessed with high molecular weight hydroxypropyl methylcellulose in a twin-screw extruder. The work studies …