Journal article
Directed Remote Aromatic Metalations: Mechanisms and Driving Forces
Abstract
Directed remote aromatic metalations are useful synthetic transformations allowing for rapid regioselective access to elaborate highly substituted carbocyclic aromatic and heteroaromatic systems. This review unravels the tangle of data reported on directed remote aromatic metalations. Through a careful analysis of critically selected examples, advanced rationalizations of remote metalation regioselectivities are presented. These extend beyond …
Authors
Tilly D; Magolan J; Mortier J
Journal
Chemistry - A European Journal, Vol. 18, No. 13, pp. 3804–3820
Publisher
Wiley
Publication Date
March 26, 2012
DOI
10.1002/chem.201103920
ISSN
0947-6539