Combined Pd/C and Montmorillonite Catalysis for One-Pot Synthesis of Benzimidazoles Academic Article uri icon

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abstract

  • A series of nineteen benzimidazoles are prepared from ortho-nitroanilines via one-pot transfer hydrogenation, condensation, and dehydrogenation enabled by the concurrent use of two heterogeneous catalysts: montmorillonite-K10 and Pd/C. This strategy is further employed to accomplish a five-step, three-component synthesis of an antifungal benzimidazoquinazoline using a simple one-pot procedure.

publication date

  • October 22, 2012