Identification of amino acid variation in the prion protein associated with classical scrapie in Canadian dairy goats

BackgroundA clear association of amino acid variation in the prion protein gene (PRNP) with susceptibility and resistance to classical scrapie exists in sheep, but not in goats. In this study we examined DNA sequence variation in the PRNP of 149 animals from two scrapie-infected herds of Saanen dairy goats, and identified 6 non-synonymous variants in the coding region.ResultsIn the larger herd, all of the 54 scrapie-affected goats tested had at …