Influence of Inflammation on Voriconazole Metabolism Academic Article uri icon

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abstract

  • ABSTRACTVoriconazole pharmacokinetics shows a large inter- and intrapatient variability. Inflammation is associated with changes in the expression of CYP isoenzymes. Here, we evaluated the influence of inflammation, marked by C-reactive protein (CRP) levels in blood, on the metabolism of voriconazole. Observational data showed an association between CRP level and the ratio of voriconazoleN-oxide to voriconazole.

publication date

  • May 2015