Nanomaterials for Ocular Drug Delivery Journal Articles

abstract

• AbstractEfficient drug delivery to the eye remains a challenging task for pharmaceutical scientists. Due to the various anatomical barriers and the clearance mechanisms prevailing in the eye, conventional drug delivery systems, such as eye drop solutions, suffer from low bioavailability. More invasive methods, such as intravitreal injections and implants, cause adverse effects in the eye. Recently, an increasing number of scientists have turned to nanomaterial‐based drug delivery systems to address the challenges faced by conventional methods. This paper highlights recent applications of various nanomaterials, such as polymeric micelles, hydrogels, liposomes, niosomes, dendrimers, and cyclodextrins as ocular drug delivery systems to enhance the bioavailability of ocular therapeutic agents.magnified image

authors

• Liu, Shengyan
• Jones, Lyndon
• Gu, Frank X

status

• published 

publication date

• May 2012

has subject area

• 0303 Macromolecular and Materials Chemistry (FoR)
• 0903 Biomedical Engineering (FoR)
• 0904 Chemical Engineering (FoR)
• Biological Availability (MeSH)
• Cyclodextrins (MeSH)
• Dendrimers (MeSH)
• Drug Delivery Systems (MeSH)
• Eye (MeSH)
• Eye Diseases (MeSH)
• Humans (MeSH)
• Hydrogels (MeSH)
• Intravitreal Injections (MeSH)
• Liposomes (MeSH)
• Micelles (MeSH)
• Nanostructures (MeSH)
• Ophthalmic Solutions (MeSH)
• Polymers (Science Metrix)

published in

• Macromolecular Bioscience  Journal

keywords

• Biological Availability
• Cyclodextrins
• Dendrimers
• Drug Delivery Systems
• Eye
• Eye Diseases
• Humans
• Hydrogels
• Intravitreal Injections
• Liposomes
• Micelles
• Nanostructures
• Ophthalmic Solutions

Digital Object Identifier (DOI)

• 10.1002/mabi.201100419

PubMed ID

• 22508445

start page

• 608

end page

• 620

volume

• 12

issue

• 5