Oral contraceptives and the risk of venous thromboembolism: An update Academic Article uri icon

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  • OBJECTIVE: To provide current and emerging evidence on oral contraceptives and the risk of venous thromboembolism. EVIDENCE: Articles published in English from 2005 were retrieved through searches of PubMed and Medline, using the following terms: venous thromboembolism, VTE, contraception, oral contraceptives, hormonal contraception. Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies. Searches were updated on a regular basis and incorporated in the guideline to May 2010. Grey (unpublished) literature was identified through searching the websites of health technology assessment and health technology assessment-related agencies, clinical practice guideline collections, clinical trial registries, and national and international medical specialty societies. VALUES: The quality of evidence was rated using the criteria described by the Canadian Task Force on Preventive Health Care (Table).


  • Reid, Robert
  • Leyland, Nicholas
  • Wolfman, Wendy
  • Allaire, Catherine
  • Awadalla, Alaa
  • Best, Carolyn
  • Dunn, Sheila
  • Lemyre, Madeleine
  • Marcoux, Violaine
  • Menard, Chantal
  • Potestio, Frank
  • Rittenberg, David
  • Singh, Sukhbir
  • Senikas, Vyta

publication date

  • March 2011