Carboxymethyl and hydrazide functionalized β-cyclodextrin derivatives: A systematic investigation of complexation behaviours with the model hydrophobic drug dexamethasone

Cyclodextrins (CDs) are typically functionalized to increase their solubility or provide reactive functional groups suitable for grafting onto polymer supports designed for controlled release applications. In this work, a systematic investigation was performed on the binding behaviour of the model drug dexamethasone with βCD derivatives functionalized with a small, negatively charged moiety (carboxyl groups, CM) and a large, neutral, reactive …