Journal article
The sisyl (tris(trimethylsilyl)silyl) group: A fluoride resistant, photolabile alcohol protecting group
Abstract
The use of the tris(trimethylsilyl)silyl (sisyl) group as a photolabile protecting group for primary and secondary alcohols was demonstrated. Sisyl ethers of a number of alcohols (yields 70–97%) were stable to many synthetic protocols, but could be deprotected using photolysis to give the starting alcohols (yields 62–95%).
Authors
Brook MA; Gottardo C; Balduzzi S; Mohamed M
Journal
Tetrahedron Letters, Vol. 38, No. 40, pp. 6997–7000
Publisher
Elsevier
Publication Date
October 1997
DOI
10.1016/s0040-4039(97)01673-0
ISSN
0040-4039