Monitoring the Distribution of Covalently Tethered Sugar Moieties in Sol−Gel-Based Silica Monoliths with Fluorescence Anisotropy: Implications for Entrapped Enzyme Activity

Biocompatible silica derived from diglycerylsilane (DGS) and the sugar modified silane N-(3-triethoxysilylpropyl)gluconamide (GLS) has been shown to have great utility for the entrapment of a number of delicate proteins. To further understand the nature of the DGS/GLS composite material, it is important to characterize the local microenvironment and properties of the silica surface within the DGS/GLS monoliths. In this work, we have monitored …