Jeffrey Pernica
Associate Professor, Pediatrics

Dr. Jeffrey Pernica, MSc MD FRCPC DTMH, is the Head of the Division of Infectious Disease and Associate Professor in the Department of Pediatrics at McMaster University. His clinical interests, aside from infectious disease in general, include tropical medicine (he is a member of the Canadian Committee to Advise on Tropical Medicine and Travel), immunization (he is the director of the Special Immunization Clinic at McMaster Children’s Hospital), and congenital CMV (he is the regional lead for the Ontario CMV newborn screening program).

His research interests relate to the optimization of the diagnosis and treatment of respiratory infections, enteric infections, and sepsis, both for children living in resource-rich as well as resource-limited settings. He has long been involved in global child health and global health research, having worked on retrospective cohort studies, prospective cohort studies, and randomized trials in Botswana and other low- and middle-income countries.

He was the recipient of a Hamilton Health Sciences Early Career Award and an IDWeek 2020 Investigator Award. He has received research funding as PI from Hamilton Health Sciences, the Physicians’ Services Incorporated Foundation, the Hamilton Academic Health Sciences Organization Innovation Fund, and Grand Challenges Canada.
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Scholarly Activity in McMaster Experts
 
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selected scholarly activity

  • academic article

    • Antimicrobial treatment duration for uncomplicated bloodstream infections in critically ill children: a multicentre observational study.  BMC Pediatrics.  22:179. 2022
    • Physician vaccination practices in mild to moderate inborn errors of immunity and retrospective review of vaccine completeness in IEI: results from the Canadian Immunization Research Network.  Canadian Journal of Allergy and Clinical Immunology Allergy, Asthma and Clinical Immunology.  18:32. 2022
    • Molecular characterization of sapovirus from children with gastroenteritis in Botswana.  Journal of Clinical Virology Plus.  2:100077-100077. 2022
    • Optimising the management of childhood acute diarrhoeal disease using a rapid test-and- treat strategy and/or Lactobacillus reuteri DSM 17938: a multicentre, randomised, controlled, factorial trial in Botswana.  BMJ Global Health.  7:e007826-e007826. 2022
    • Bleach baths for atopic dermatitis.  Annals of Allergy, Asthma and Immunology.  2022
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    • Assessment of nasopharyngeal Streptococcus pneumoniae colonization does not permit discrimination between Canadian children with viral and bacterial respiratory infection: a matched-cohort cross-sectional study.  BMC Infectious Diseases.  21:509. 2021
    • Epidemiology, clinical features and outcomes of incident tuberculosis in children in Canada in 2013–2016: results of a national surveillance study.  Archives of Disease in Childhood.  106:1165-1170. 2021
    • Citrobacter koseri meningitis and septicemia in a neonate with borderline fever at home.  CMAJ.  193:E1592-E1594. 2021
    • SARS-CoV-2 antibodies in Ontario health care workers during and after the first wave of the pandemic: a cohort study.  Canadian Journal of Surgery.  9:E929-E939. 2021
    • Single-centre, open-label, randomised, trial to compare rapid molecular point-of-care streptococcal testing to standard laboratory-based testing for the management of streptococcal pharyngitis in children: study protocol.  BMJ Open.  11:e047271-e047271. 2021
    • Short-Course Antimicrobial Therapy for Pediatric Community-Acquired Pneumonia.  Archives of Pediatrics and Adolescent Medicine.  175:475-475. 2021
    • Self-Collected Saline Gargle Samples as an Alternative to Health Care Worker-Collected Nasopharyngeal Swabs for COVID-19 Diagnosis in Outpatients.  Journal of Clinical Microbiology.  59:e02427-e02420. 2021
    • Risk of latent and active tuberculosis infection in travellers: a systematic review and meta-analysis.  Journal of Travel Medicine.  28:taaa214. 2021
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    • Waning Vaccine Immunity and Vaccination Responses in Children Treated for Acute Lymphoblastic Leukemia: A Canadian Immunization Research Network Study.  Clinical Infectious Diseases.  71:e439-e448. 2020
    • Global molecular diversity of RSV – the “INFORM RSV” study.  BMC Infectious Diseases.  20:450. 2020
    • Starving the Gut: A Deficit of Butyrate in the Intestinal Ecosystem of Children With Intestinal Failure.  Journal of Parenteral and Enteral Nutrition.  44:1112-1123. 2020
    • Fast I(n)dentification of Pathogens in Neonates (FINDPATH-N): protocol for a prospective pilot cohort study of next-generation sequencing for pathogen identification in neonates with suspected sepsis.  BMJ Paediatrics Open.  4:e000651-e000651. 2020
    • Paediatric critical illness associated with respiratory infection: a single-centre, retrospective cohort study.  BMJ Paediatrics Open.  4:e000640-e000640. 2020
    • Evaluation of Anatomically Designed Flocked Rectal Swabs for Use with the BioFire FilmArray Gastrointestinal Panel for Detection of Enteric Pathogens in Children Admitted to Hospital with Severe Gastroenteritis.  Journal of Clinical Microbiology.  57:e00962-e00919. 2019
    • Diversity of Rotavirus Strains Circulating in Botswana before and after introduction of the Monovalent Rotavirus Vaccine.  Vaccine.  37:6324-6328. 2019
    • Glucose-6-phosphate dehydrogenase deficiency genotypes and allele frequencies in the Kavango and Zambezi regions of northern Namibia.  Transactions of the Royal Society of Tropical Medicine and Hygiene.  113:483-488. 2019
    • Molecular detection of P. vivax and P. ovale foci of infection in asymptomatic and symptomatic children in Northern Namibia.  PLoS Neglected Tropical Diseases.  13:e0007290-e0007290. 2019
    • New Tools to Test Stool.  Infectious Disease Clinics of North America.  33:197-212. 2019
    • Pediatric Investigators Collaborative Network on Infections in Canada Study of Respiratory Syncytial Virus–associated Deaths in Pediatric Patients in Canada, 2003–2013.  Clinical Infectious Diseases.  68:113-119. 2019
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    • Noninferiority Margin Size and Acceptance of Trial Results: Contingent Valuation Survey of Clinician Preferences for Noninferior Mortality.  Medical Decision Making.  0272989X2210994-0272989X2210994.

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