selected scholarly activity
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conferences
- IN VITRO EVALUATION OF THE AEROGEN MICROPUMP AEROSOL DELIVERY SYSTEM FOR DELIVERING ADHU5AG85A TB VACCINE TO HUMAN SUBJECTS. Journal of Aerosol Medicine and Pulmonary Drug Delivery. A12-A12. 2015
- CURRENT METHODS FOR LUNG IMAGING OF AEROSOL DEPOSITION FROM MEDICAL INHALERS: GUIDELINES FROM THE ISAM TASK FORCE REPORT. Journal of Aerosol Medicine and Pulmonary Drug Delivery. A13-A13. 2013
- LUNG DEPOSITION OF QVAR (HFA134A-BDP) IN NEWBORN INFANTS WITH BRONCHOPULMONARY DYSPLASIA (BPD). Chest. 351S-351S. 2005
- Improved Aerosolization of Suspensions Using Electronic Micropump Technology Compared to Conventional Pneumatic Nebulization. Chest. 816S-816S. 2004
- Predicting in vivo aerosol delivery using simulated breathing patterns. Journal of Allergy and Clinical Immunology. S244-S244. 2002
- Use of dynamic spiral CT to evaluate vocal chord geometry during inhalations from two DPIs at varying inspiratory flow rates.. American Journal of Respiratory and Critical Care Medicine. A120-A120. 1999
- 109 PULMONARY DEPOSITION OF SALBUTAMOL AEROSOL DELIVERED BY METERED DOSE INHALER (MDI), JET NEBULIZER AND ULTRASONIC NEBULIZER IN MECHANICALLY VENTILATED RABBITS. Pediatric Research. 21A-21A. 1994
- DELIVERY OF SALBUTAMOL (S) TO INFANTS WITH BRONCHOPULMONARY DYSPLASIA (BPD) BY METERED-DOSE INHALER (MDI) AND JET NEBULIZER (JET). Pediatric Research. A332-A332. 1994
- SALBUTAMOL ADMINISTRATION FOR CHILDREN UNDER 3 BY MEANS OF A MASK AEROCHAMBER UNIT. Clinical and Investigative Medicine. A179-A179. 1985
- SITES OF AIR-FLOW LIMITATION IN EARLY AND LATE ASTHMATIC RESPONSES TO ALLERGEN AEROSOL. Australian and New Zealand Journal of Medicine. 93-93. 1981
- ALLERGEN-INDUCED INCREASE IN NON-ALLERGIC AIRWAY RESPONSIVENESS TO HISTAMINE. Journal of Allergy and Clinical Immunology. 207-207. 1980
- BRONCHIAL PROVOCATION TESTS - EVALUATION OF 2 TECHNIQUES OF AEROSOL INHALATION. Journal of Allergy and Clinical Immunology. 206-207. 1980
- PREFERENTIAL DEPOSITION OF ALLERGEN - INFLUENCE ON SEVERITY AND PATTERN OF RESPONSE. Journal of Allergy and Clinical Immunology. 208-208. 1980
- CYSTIC-FIBROSIS MUCOCILIARY INHIBITOR (CFMI) - INVIVO EFFECT IN MAN. American Review of Respiratory Disease. 281-281. 1979
- EFFECTS OF POSTURAL DRAINAGE, EXERCISE, AND COUGH ON MUCUS TRANSPORT IN CHRONIC-BRONCHITIS. Clinical Research. A878-A878. 1978
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journal articles
- Internal microstructure of spray dried particles affects viral vector activity in dry vaccines. International Journal of Pharmaceutics. 640:122988-122988. 2023
- Design Considerations for Intratracheal Delivery Devices to Achieve Proof-of-Concept Dry Powder Biopharmaceutical Delivery in Mice. Pharmaceutical Research. 40:1165-1176. 2023
- Comparison of ventilation defects quantified by Technegas SPECT and hyperpolarized 129Xe MRI. Frontiers in Physiology. 14:1133334. 2023
- Corrigendum to “Screening amino acid additives as aerosolization modifiers for spray dried inhalable viral-vectored vaccines” [J. Drug Discov. Sci. Technol. 76 (2022) 1773–2247/103815]. Journal of Drug Delivery Science and Technology. 78:103926-103926. 2022
- Screening amino acid additives as aerosolization modifiers for spray dried inhalable viral-vectored vaccines. Journal of Drug Delivery Science and Technology. 76:103815-103815. 2022
- Ventilation and perfusion abnormalities following recovery from noncritical COVID-19. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 6:304-313. 2022
- Dextran Mass Ratio Controls Particle Drying Dynamics in a Thermally Stable Dry Powder Vaccine for Pulmonary Delivery. Pharmaceutical Research. 39:2315-2328. 2022
- Aerosol delivery, but not intramuscular injection, of adenovirus-vectored tuberculosis vaccine induces respiratory-mucosal immunity in humans. JCI insight. 7:e155655. 2022
- A regional Canadian expert consensus on recommendations for restoring exercise and pulmonary function testing in low and moderate-to-high community prevalence coronavirus disease 2019 (COVID-19) settings. Infection Control and Hospital Epidemiology. 42:1535-1537. 2021
- Forgotten Technology in the COVID-19 Pandemic: Filtration Properties of Cloth and Cloth Masks—A Narrative Review. Mayo Clinic proceedings. 95:2204-2224. 2020
- Cloth Masks May Prevent Transmission of COVID-19: An Evidence-Based, Risk-Based Approach. ACP journal club. 173:489-491. 2020
- Efficiency of budesonide delivery via a mesh nebulizer in an in‐vitro neonatal ventilator model. Pediatric Pulmonology. 55:2283-2288. 2020
- Studies of Radioaerosol Deposition in the Respiratory Tract. Seminars in Nuclear Medicine. 49:62-70. 2019
- Relationship of Inhaled Corticosteroid Adherence to Asthma Exacerbations in Patients with Moderate-to-Severe Asthma. Journal of Allergy and Clinical Immunology: In Practice. 6:1989-1998.e3. 2018
- Re: “Harmonizing the Nomenclature for Therapeutic Aerosol Particle Size: A Proposal” by Hillyer et al. (J Aerosol Med Pulm Drug Deliv. 2018 [31(2):111–113]; DOI: 10/1089/jamp.2017.1396). Journal of Aerosol Medicine and Pulmonary Drug Delivery. 31:266-268. 2018
- Errors in the Use of Inhalers by Health Care Professionals: A Systematic Review. Journal of Allergy and Clinical Immunology: In Practice. 6:987-995. 2018
- Real-Life Outcomes for Patients with Asthma Prescribed Spacers for Use with Either Extrafine- or Fine-Particle Inhaled Corticosteroids. Journal of Allergy and Clinical Immunology: In Practice. 5:1040-1049.e4. 2017
- Airway Hyperresponsiveness in Asthma: Measurement and Clinical Relevance. Journal of Allergy and Clinical Immunology: In Practice. 5:649-659.e2. 2017
- Patient Focus and Regulatory Considerations for Inhalation Device Design: Report from the 2015 IPAC-RS/ISAM Workshop. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 30:1-13. 2017
- The use of multiple respiratory inhalers requiring different inhalation techniques has an adverse effect on COPD outcomes. International Journal of COPD. Volume 12:59-71. 2017
- Airway Epithelial Cell Cilia and Obstructive Lung Disease. Cells. 5:40-40. 2016
- In VitroEvaluation of a Device for Intra-Pulmonary Aerosol Generation and Delivery. Aerosol Science and Technology. 49:747-752. 2015
- In Vitro Testing for Orally Inhaled Products: Developments in Science-Based Regulatory Approaches. AAPS Journal. 17:837-852. 2015
- Positron Emission Tomography (PET) for Assessing Aerosol Deposition of Orally Inhaled Drug Products. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 25:S52-S71. 2012
- Standardization of Techniques for Using Planar (2D) Imaging for Aerosol Deposition Assessment of Orally Inhaled Products. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 25:S10-S28. 2012
- Standards for Lung Imaging Techniques. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 25:S1-S2. 2012
- Ciliary beating is depressed in nasal cilia from chronic obstructive pulmonary disease subjects. Respiratory Medicine. 106:1139-1147. 2012
- Clinically Relevant Test Methods to EstablishIn VitroEquivalence for Spacers and Valved Holding Chambers Used with Pressurized Metered Dose Inhalers (pMDIs). Journal of Aerosol Medicine and Pulmonary Drug Delivery. 25:217-242. 2012
- Equivalence Considerations for Orally Inhaled Products for Local Action—ISAM/IPAC-RS European Workshop Report. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 25:117-139. 2012
- The Direct Effect of Hyperosmolar Agents on Ciliary Beating of Human Bronchial Epithelial Cells. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 25:88-95. 2012
- The Role of Nebulized Therapy in the Management of COPD: Evidence and Recommendations. COPD: Journal of Chronic Obstructive Pulmonary Disease. 9:58-72. 2012
- Cystic Fibrosis Transmembrane Conductance Regulator Gene Abnormalities in Patients with Asthma and Recurrent Neutrophilic Bronchitis. Canadian Respiratory Journal. 19:46-48. 2012
- Aerosol drug delivery: developments in device design and clinical use – Authors' reply. The Lancet. 378:982-982. 2011
- Aerosol drug delivery: developments in device design and clinical use. The Lancet. 377:1032-1045. 2011
- Deposition, Imaging, and Clearance: What Remains to be Done?. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 23:S39-S57. 2010
- Primary Human Bronchial Epithelial Cells Grown from Explants. Journal of Visualized Experiments. 1789. 2010
- 18F-Fluorodeoxyglucose Positron Emission Tomographic Imaging of Pulmonary Functions, Pathology, and Drug Delivery. Annals of the American Thoracic Society. 6:477-485. 2009
- The effect of inhaled lidocaine-hydrofluoroalkane 134a in prednisone-dependent eosinophilic bronchitis. European Respiratory Journal. 32:1119-1122. 2008
- Positron Emission Tomography and Computed Tomography versus Positron Emission Tomography Computed Tomography: Tools for Imaging the Lung. Annals of the American Thoracic Society. 4:328-333. 2007
- Anti‐inflammatory effects of once daily low dose inhaled ciclesonide in mild to moderate asthmatic patients. Acta Allergologica. 61:537-542. 2006
- In Reply: Aerosol Delivery Devices. Chest. 129:1389-1389. 2006
- Synthesis and in Vitro Evaluation of18F- and19F-Labeled Insulin: A New Radiotracer for PET-based Molecular Imaging Studies. Journal of Medicinal Chemistry. 49:1466-1474. 2006
- In VitroEstimations ofIn VivoJet Nebulizer Efficiency Using Actual and Simulated Tidal Breathing Patterns. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 18:427-438. 2005
- Device Selection and Outcomes of Aerosol Therapy: Evidence-Based Guidelines. Chest. 127:335-371. 2005
- Imaging Drug Delivery and Drug Responses in the Lung. Annals of the American Thoracic Society. 1:329-337. 2004
- Canadian Standards Association Standard CAN/CSA/Z264.1‐02:2002: A New Voluntary Standard for Spacers and Holding Chambers Used with Pressurized Metered‐Dose Inhalers. Canadian Respiratory Journal. 11:489-495. 2004
- Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications. British Journal of Clinical Pharmacology. 56:588-599. 2003
- Pulmonary drug delivery. Part II: The role of inhalant delivery devices and drug formulations in therapeutic effectiveness of aerosolized medications. British Journal of Clinical Pharmacology. 56:600-612. 2003
- Uptake of18fluorodeoxyglucose in the cystic fibrosis lung: a measure of lung inflammation?. European Respiratory Journal. 21:848-854. 2003
- Clinical Models to Compare the Safety and Efficacy of Inhaled Corticosteroids in Patients with Asthma. Canadian Respiratory Journal. 10:27-34. 2003
- Assessing nebulizer performance.. Respiratory Care. 47:1290-1301. 2002
- Systemic Effect Comparisons of Six Inhaled Corticosteroid Preparations. American Journal of Respiratory and Critical Care Medicine. 165:1377-1383. 2002
- Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia. American Journal of Physiology - Lung Cellular and Molecular Physiology. 282:L833-L839. 2002
- Significant variability in response to inhaled corticosteroids for persistent asthma. Journal of Allergy and Clinical Immunology. 109:410-418. 2002
- Therapeutic equivalence of three metered‐dose inhalers containing salbutamol (Albuterol) in protecting against methacholine‐induced bronchoconstriction in children with asthma. Pediatric pulmonology. Supplement. 32:447-452. 2001
- Sputum induction: effect of nebulizer output and inhalation time on cell counts and fluid‐phase measures. Clinical and Experimental Allergy. 31:1740-1744. 2001
- Aerosols and devices. Respiratory Care Clinics of North America. 7:131-173. 2001
- Measuring Total and Regional Lung Deposition Using Inhaled Radiotracers. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 14:35-44. 2001
- Influence of inspiratory flow rate, particle size, and airway caliber on aerosolized drug delivery to the lung.. Respiratory Care. 45:597-608. 2000
- Safety and efficiency of metered dose inhaler delivery of salbutamol in the intubated rabbit. Critical Care Medicine. 28:1055-1058. 2000
- Consensus Statement: Aerosols and Delivery Devices. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 13:291-300. 2000
- Summary of recommendations from the Canadian Asthma Consensus Report, 1999. CANADIAN MEDICAL ASSOCIATION JOURNAL. 161. 1999
- New Propellant-Free Technologies under Investigation. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 12:S9-17. 1999
- A Randomized Controlled Trial on the Effect of Inhaled Corticosteroids on Airways Inflammation in Adult Cigarette Smokers. Chest. 115:1271-1277. 1999
- Randomised controlled study of early use of inhaled corticosteroid in preterm infants with respiratory distress syndrome. Archives of Disease in Childhood: Fetal and Neonatal Edition. 80:F203-F208. 1999
- Aerosol delivery to children: What to use, how to choose. Pediatric pulmonology. Supplement. 27:79-82. 1999
- Estimation of Pulmonary Deposition of Aerosol Using Gamma Scintigraphy. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 12:9-15. 1999
- New Delivery Systems and Propellants. Canadian Respiratory Journal. 6:290-295. 1999
- Nicotine Microaerosol Inhaler. Canadian Respiratory Journal. 6:509-512. 1999
- Effect of continuous lateral rotational therapy on lung mucus transport in mechanically ventilated patients. Journal of Critical Care. 13:119-125. 1998
- Impact of Oropharyngeal Deposition on Inhaled Dose. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 11:S112-S115. 1998
- Nebulisation of surfactants in an animal model of neonatal respiratory distress. Archives of Disease in Childhood: Fetal and Neonatal Edition. 78:F3-F9. 1998
- Pulmonary Deposition of Salbutamol Aerosol Delivered by Metered Dose Inhaler, Jet Nebulizer, and Ultrasonic Nebulizer in Mechanically Ventilated Rabbits. Pediatric Research. 42:721-727. 1997
- Changing delivery methods for obstructive lung diseases. Current Opinion in Pulmonary Medicine. 3:177-189. 1997
- Rationale for spacer use in children. Pediatric pulmonology. Supplement. 23:184-185. 1997
- Delivery of metered dose inhaler aerosols to paralyzed and nonparalyzed rabbits. Critical Care Medicine. 25:140-144. 1997
- Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia. Pediatric pulmonology. Supplement. 21:301-309. 1996
- In Vitro Measurements of Delivery of Medications from MDIs and Spacer Devices. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 9:S49-S58. 1996
- Metered-Dose Inhaler Salbutamol-Induced Tracheal Epithelial Lesions in Intubated Rabbits. Chest. 108:1668-1672. 1995
- Chest position and pulmonary deposition of surfactant in surfactant depleted rabbits.. Archives of Disease in Childhood: Fetal and Neonatal Edition. 72:F84-F89. 1995
- Proximate delivery of a large experimental dose from salbutamol MDI induces epithelial airway lesions in intubated rabbits.. American Journal of Respiratory and Critical Care Medicine. 150:790-794. 1994
- Dose-effect Relationship of the β-Agonists Fenoterol and Salbutamol in Patients With Asthma. Chest. 105:1738-1742. 1994
- Optimization of a column liquid chromatographic procedure for the determination of plasma salbutamol concentration. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 654:205-211. 1994
- Aerosols as Diagnostic Tools. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 7:77-88. 1994
- Efficiency of Bronchodilator Aerosol Delivery to the Lungs From the Metered Dose Inhaler in Mechanically Ventilated Patients. Chest. 105:214-218. 1994
- Dosing Efficiency and Particle-size Characteristics of Pressurized Metered-dose Inhaler Aerosols in Narrow Catheters. Chest. 103:920-924. 1993
- Standards for In Vitro/In Vivo Measurements of MDI Characteristics: Yea or Nay?. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 6:123-124. 1993
- Ciliary Function, Cell Viability, and in Vitro Effect of Ribavirin on Nasal Epithelial Cells in Acute Rhinorrhea. Chest. 102:284-287. 1992
- Aerosol Delivery During Mechanical Ventilation: A Predictive In-Vitro Lung Model. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 5:251-259. 1992
- SALBUTAMOL AEROSOL DELIVERY IN MAN WITH THE RONDO SPACER. Acta Therapeutica. 18:103-104. 1992
- The use of reservoir devices for the simultaneous delivery of two metered-dose inhalers. Journal of Allergy and Clinical Immunology. 87:599-599. 1991
- Measurement of Particle Size Characteristics of Metered Dose Inhaler (MDI) Aerosols. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 4:251-263. 1991
- Replacing CFC aerosols with powders.. CANADIAN MEDICAL ASSOCIATION JOURNAL. 142:1036. 1990
- Pressurized Aerosol versus Jet Aerosol Delivery to Mechanically Ventilated Patients Comparison of Dose to the Lungs. American Journal of Respiratory and Critical Care Medicine. 141:440-444. 1990
- Antigen-induced Lung Solute Clearance in Rats Is Dependent on Capsaicin-sensitive Nerves. American Journal of Respiratory and Critical Care Medicine. 139:401-406. 1989
- Reliable salbutamol administration in 6‐ to 36‐month‐old children by means of a metered dose inhaler and aerochamber with mask. Pediatric pulmonology. Supplement. 6:263-267. 1989
- Lung clearance of 99mTc-DTPA in patients with acute lung injury and pulmonary edema. Journal of Thoracic Imaging. 3:21-27. 1988
- Solute Movement across the Alveolar-Capillary Membrane after Intratracheally Administered Bleomycin in Rats. American Journal of Respiratory and Critical Care Medicine. 138:96-100. 1988
- Lung epithelial permeability in sarcoidosis.. Sarcoidosis Vasculitis and Diffuse Lung Diseases. 4:116-121. 1987
- Evaluation of lung epithelial permeability. European Journal of Nuclear Medicine and Molecular Imaging. 13:S58-S62. 1987
- Methodologic considerations in mucociliary clearance and lung epithelial absorption measurements. European Journal of Nuclear Medicine and Molecular Imaging. 13:S45-S52. 1987
- Control of Asthma by Aerosols. New England Journal of Medicine. 315:870-874. 1986
- Albuterol nebulizer solution for the treatment of asthma.. Annals of Allergy, Asthma and Immunology. 57:229. 1986
- Lung epithelial permeability: relation to nonspecific airway responsiveness. Journal of applied physiology. 57:77-84. 1984
- The preferential deposition of inhaled isoproterenol and propranolol in asthmatic patients. Chest. 80:904-907. 1981
- The preferential deposition of inhaled isoproterenol and propranolol in asthmatic patients.. Chest. 80:904-907. 1981
- Standardization of inhalation provocation tests: Influence of nebulizer output, particle size, and method of inhalation. Journal of Allergy and Clinical Immunology. 67:156-161. 1981
- Standardization of inhalation provocation tests: two techniques of aerosol generation and inhalation compared.. American Journal of Respiratory and Critical Care Medicine. 123:195-199. 1981
- Effects of postural drainage, exercise, and cough on mucus clearance in chronic bronchitis.. American Journal of Respiratory and Critical Care Medicine. 120:739-745. 1979
- Aerosol Therapy with Sch 1000. Chest. 73:501-506. 1978
- The effects of preferential deposition of histamine in the human airway.. American Journal of Respiratory and Critical Care Medicine. 117:485-492. 1978
- EFFECTS OF PREFERENTIAL DEPOSITION OF HISTAMINE IN HUMAN AIRWAY - REPLY. American Review of Respiratory Disease. 118:446-446. 1978
- Effects of exercise and eucapnic hyperventilation on bronchial clearance in man. Journal of applied physiology. 43:46-50. 1977
- Pulmonary aerosol deposition in chronic bronchitis: intermittent positive pressure breathing versus quiet breathing.. American Journal of Respiratory and Critical Care Medicine. 115:397-402. 1977
- Impairment of mucociliary transport in cystic fibrosis.. Modern problems in paediatrics. 19:190-198. 1976
- Aerosol penetrance: a sensitive index of peripheral airways obstruction. Journal of applied physiology. 40:468-471. 1976
- Steady state measurement of regional ventilation to perfusion ratios in normal man.. Journal of Clinical Investigation. 45:1349-1356. 1966
- Regional distribution of inspired gas in the lung.. Journal of applied physiology. 21:749-759. 1966
- Regional distribution of ventilation and perfusion as a function of body position.. Journal of applied physiology. 21:767-777. 1966