selected scholarly activity
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academic article
- BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage. Nature Communications. 11:4083. 2020
- Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints. Nature Communications. 11:4124. 2020
- Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. Nature Communications. 10:2400. 2019
- Antibody-targeting of ultra-small nanoparticles enhances imaging sensitivity and enables longitudinal tracking of multiple myeloma. Nanoscale. 11:20485-20496. 2019
- Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. Nature Communications. 9:1991. 2018
- The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science The Scientific monthly. 354:765-768. 2016
- Kicking Genomic Profiling to the Curb: How Re-wiring the Phosphoproteome Can Explain Treatment Resistance in Glioma. Cancer Cell. 29:435-436. 2016
- Stereotactic radiosurgery for brain metastases from malignant melanoma. Surgical Neurology International. 6:355-355. 2015
- Primary Extradural Tumors of the Spine - Case Review with Evidence-guided Management. Surgical Neurology International. 5:373-373. 2014
- The effect of screw head design on rod derotation in the correction of thoracolumbar spinal deformity. Journal of Neurosurgery: Spine. 19:351-359. 2013
- The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature Nature: New biology. 498:246-250. 2013
- Arteriovenous fistula and pseudoaneurysm of the anterior spinal artery caused by an epidural needle in a 5-year-old patient. Journal of Neurosurgery: Pediatrics. 11:340-345. 2013
- Fibrin sealant augmentation with autologous pericranium for duraplasty after suboccipital decompression in Chiari 1 patients: A case series. Surgical Neurology International. 4:6-6. 2013
- Augmented Autologous Pericranium Duraplasty in 100 Posterior Fossa Surgeries—A Retrospective Case Series. Operative Neurosurgery. 71:ons302-ons307. 2012
- Primary epidural lymphocyte-depleted Hodgkin’s lymphoma of the thoracic spine – presentation of a rare disease variant. BMC Neurology. 12:64. 2012
- The Effects of Design and Positioning of Carbon Fiber Lumbar Interbody Cages and Their Subsidence in Vertebral Bodies. Journal of Spinal Disorders and Techniques. 25:116-122. 2012
- "Hitting all the right markers to save a life" Solitary fibrous tumors of the central nervous system: Case series and review of the literature. Surgical Neurology International. 3:83-83. 2012
- "Time is brain" the Gifford factor - or: Why do some civilian gunshot wounds to the head do unexpectedly well? A case series with outcomes analysis and a management guide. Surgical Neurology International. 3:98-98. 2012
- An anterior approach to spinal pathology of the upper thoracic spine through a partial manubriotomy. Journal of Neurosurgery: Spine. 15:467-471. 2011
- Reoperations After Decompression for Lumbar Spinal Stenosis. World Neurosurgery. 76:51-53. 2011
- Thoracolumbar spinal deformity: Part II. Developments from 1990 to today. Journal of Neurosurgery: Spine. 11:640-650. 2009
- Cervical spine instability following cervical laminectomies for Chiari II malformation: a retrospective cohort study. Child's Nervous System. 25:71-76. 2009
- Spondylolisthesis of C2 in an Eight-Week-Old Infant: Long Term Followup. Canadian Journal of Neurological Sciences. 34:372-374. 2007
- Treatment of Secondary Tonsillar Herniation by Lumboperitoneal Shunt Revision. Canadian Journal of Neurological Sciences. 34:237-242. 2007
- β-Amyloid efflux mediated by p-glycoprotein. Journal of Neurochemistry. 76:1121-1128. 2001
- Regulation of Amyloid Precursor Protein Catabolism Involves the Mitogen-Activated Protein Kinase Signal Transduction Pathway. Journal of Neuroscience. 17:9415-9422. 1997
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conference paper
- BROMODOMAIN INHIBITORS INDUCE DOWNREGULATION OF DNA DAMAGE REPAIR PATHWAYS AND OFFER NOVEL SYNERGISTIC COMBINATIONS WITH ENHANCED SAFETY PROFILES FOR THE TREATMENT OF MEDULLOBLASTOMA AND GLIOBLASTOMA. Neuro-Oncology. 118-118. 2019
- NEURONAL DIFFERENTIATION AND CELL-CYCLE PROGRAMS MEDIATE. RESPONSE AND RESISTANCE TO BET-BROMODOMAIN INHIBITION IN MYC-DRIVEN MEDULLOBLASTOMA. Neuro-Oncology. 111-111. 2019
- A VERSATILE AND MODULAR TARGETED NANOPARTICLE PLATFORM FOR DELIVERY OF COMBINATION THERAPIES TO ADULT AND PEDIATRIC CNS TUMORS. Neuro-Oncology. 277-277. 2018
- A VERSATILE AND MODULAR TARGETED NANOPARTICLE PLATFORM FOR DELIVERY OF COMBINATION THERAPIES TO ADULT AND PEDIATRIC CNS TUMORS. Neuro-Oncology. 87-87. 2018
- ENHANCED IN VIVO EFFICACY AND SAFETY OF COMBINATION TEMOZOLOMIDE AND BROMODOMAIN INHIBITOR THERAPY FOR GLIOMAS USING A TARGETED DUAL DRUG-LOADING STEALTH LIPOSOMAL CARRIER. Neuro-Oncology. 273-273. 2017
- ENHANCED IN VIVO EFFICACY AND SAFETY OF COMBINATION TEMOZOLOMIDE AND BROMODOMAIN INHIBITOR THERAPY FOR GLIOMAS USING A TARGETED DUAL DRUG-LOADING STEALTH LIPOSOMAL CARRIER. Neuro-Oncology. 73-73. 2017
- Nicotine's effects on cognitive effort are dependent upon individual differences: Acetylcholine manipulation on a rodent cost/benefit decision-making task. International Journal of Neuropsychopharmacology. 160-160. 2014