Journal of Clinical Endocrinology and Metabolism
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Overview
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Impact of Vertebral Fractures and Glucocorticoid Exposure on Height Deficits in Children During Treatment of Leukemia.
104:213-222.
2019
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The Relationship Between the Score on a Simple Measure of Cognitive Function and Incident CVD in People With Diabetes: A Post Hoc Epidemiological Analysis From the ACCORD-MIND Study.
102:3218-3225.
2017
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Validation of the ORIGIN Cardiovascular Biomarker Panel and the Value of Adding Troponin I in Dysglycemic People.
102:2251-2257.
2017
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Piloting a Remission Strategy in Type 2 Diabetes: Results of a Randomized Controlled Trial.
102:1596-1605.
2017
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Attenuation of Resting but Not Load-Mediated Protein Synthesis in Prostate Cancer Patients on Androgen Deprivation.
102:1076-1083.
2017
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Letter to the Editor: Models Developed Using Small Datasets Should be Appropriately Evaluated.
101:L104-L105.
2016
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Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline.
101:364-389.
2016
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Cognitive Performance at Late Adolescence and the Risk for Impaired Fasting Glucose Among Young Adults.
100:4409-4416.
2015
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Menopausal Hormone Therapy and Mortality: A Systematic Review and Meta-Analysis.
100:4021-4028.
2015
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Oral vs Transdermal Estrogen Therapy and Vascular Events: A Systematic Review and Meta-Analysis.
100:4012-4020.
2015
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Incident Vertebral Fractures in Children With Leukemia During the Four Years Following Diagnosis.
100:3408-3417.
2015
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Dysglycemia and Cognitive Dysfunction and Ill Health in People With High CV Risk: Results From the ONTARGET/TRANSCEND Studies.
100:2682-2689.
2015
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Sex Differences in the Effects of Weight Loss Diets on Bone Mineral Density and Body Composition: POUNDS LOST Trial.
100:2463-2471.
2015
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Cancer-Related Worry in Canadian Thyroid Cancer Survivors.
100:977-985.
2015
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The Choice of Normative Pediatric Reference Database Changes Spine Bone Mineral Density Z-Scores But Not the Relationship Between Bone Mineral Density and Prevalent Vertebral Fractures.
100:1018-1027.
2015
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Drugs Commonly Associated With Weight Change: A Systematic Review and Meta-analysis.
100:363-370.
2015
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Medical Management of Primary Hyperparathyroidism: Proceedings of the Fourth International Workshop on the Management of Asymptomatic Primary Hyperparathyroidism.
99:3607-3618.
2014
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The Benefits and Harms of Systemic Dehydroepiandrosterone (DHEA) in Postmenopausal Women With Normal Adrenal Function: A Systematic Review and Meta-analysis.
99:3536-3542.
2014
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The Benefits and Harms of Systemic Testosterone Therapy in Postmenopausal Women With Normal Adrenal Function: A Systematic Review and Meta-analysis.
99:3543-3550.
2014
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Effect of Odanacatib on BMD and Fractures: Estimates from Bayesian Univariate and Bivariate Meta-analyses.
99:3070-3079.
2014
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The Accuracy of Thyroid Nodule Ultrasound to Predict Thyroid Cancer: Systematic Review and Meta-Analysis.
99:1253-1263.
2014
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Efficacy of Vitamin D Supplementation in Depression in Adults: A Systematic Review.
99:757-767.
2014
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Empirically Based Composite Fracture Prediction Model From the Global Longitudinal Study of Osteoporosis in Postmenopausal Women (GLOW).
99:817-826.
2014
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Erratum.
99:1096-1096.
2014
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Adverse Effects of the Common Treatments for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.
98:4646-4654.
2013
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Endurance Training Modulates Intramyocellular Lipid Compartmentalization and Morphology in Skeletal Muscle of Lean and Obese Women.
98:4852-4862.
2013
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Lifestyle Modification Programs in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis.
98:4655-4663.
2013
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Glucose Targets in Pregnant Women With Diabetes: A Systematic Review and Meta-Analysis.
98:4319-4324.
2013
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Screening for Gestational Diabetes: A Systematic Review and Meta-Analysis.
98:4311-4318.
2013
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The Endocrine Society Guidelines: When the Confidence Cart Goes Before the Evidence Horse.
98:3246-3252.
2013
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Calcium and Vitamin D Intake and Mortality: Results from the Canadian Multicentre Osteoporosis Study (CaMos).
98:3010-3018.
2013
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Skeletal Muscle Abnormalities in Girls and Adolescents With Turner Syndrome.
98:2521-2527.
2013
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Two Weeks of Reduced Activity Decreases Leg Lean Mass and Induces “Anabolic Resistance” of Myofibrillar Protein Synthesis in Healthy Elderly.
98:2604-2612.
2013
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Up-Regulation of the Complement System in Subcutaneous Adipocytes from Nonobese, Hypertriglyceridemic Subjects Is Associated with Adipocyte Insulin Resistance.
97:4742-4752.
2012
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Comparative Effectiveness of Drug Treatments to Prevent Fragility Fractures: A Systematic Review and Network Meta-Analysis.
97:1871-1880.
2012
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Risk Factors for Low Bone Mass-Related Fractures in Men: A Systematic Review and Meta-Analysis.
97:1861-1870.
2012
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Diets Higher in Dairy Foods and Dietary Protein Support Bone Health during Diet- and Exercise-Induced Weight Loss in Overweight and Obese Premenopausal Women.
97:251-260.
2012
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Glycemic Control in Non-Critically Ill Hospitalized Patients: A Systematic Review and Meta-Analysis.
97:49-58.
2012
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Management of Hyperglycemia in Hospitalized Patients in Non-Critical Care Setting: An Endocrine Society Clinical Practice Guideline.
97:16-38.
2012
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Continuous Glucose Monitoring: An Endocrine Society Clinical Practice Guideline.
96:2968-2979.
2011
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The Effect of Vitamin D on Falls: A Systematic Review and Meta-Analysis.
96:2997-3006.
2011
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Vitamin D and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis.
96:1931-1942.
2011
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Treatment with Denosumab Reduces the Incidence of New Vertebral and Hip Fractures in Postmenopausal Women at High Risk.
96:1727-1736.
2011
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Childhood Obesity Is Associated with Shorter Leukocyte Telomere Length.
96:1500-1505.
2011
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Modified-Release Recombinant Human TSH (MRrhTSH) Augments the Effect of131I Therapy in Benign Multinodular Goiter: Results from a Multicenter International, Randomized, Placebo-Controlled Study.
96:1368-1376.
2011
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Natural History of Nonfunctioning Pituitary Adenomas and Incidentalomas: A Systematic Review and Metaanalysis.
96:905-912.
2011
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Patient Guide to Pituitary Incidentaloma Assessment and Treatment.
96:35A-36A.
2011
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Pituitary Incidentaloma: An Endocrine Society Clinical Practice Guideline.
96:894-904.
2011
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Diagnosis and Treatment of Hyperprolactinemia: An Endocrine Society Clinical Practice Guideline.
96:273-288.
2011
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Association of 25(OH)D and PTH with Metabolic Syndrome and Its Traditional and Nontraditional Components.
96:168-175.
2011
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Association of Hematological Parameters with Insulin Resistance and beta-Cell Dysfunction in Nondiabetic Subjects (vol 94, pg 3824, 2009).
95:5465-5465.
2010
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Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline (vol 95, pg 4133, 2010).
95:S137-S137.
2010
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Adult Height in Patients with Congenital Adrenal Hyperplasia: A Systematic Review and Metaanalysis.
95:4161-4172.
2010
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Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline.
95:4133-4160.
2010
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Adverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis.
95:2560-2575.
2010
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Testosterone Therapy in Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline.
95:2536-2559.
2010
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Prenatal Determinants of Uterine Volume and Ovarian Reserve in Adolescence.
94:4931-4937.
2009
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Skeletal Muscle Lipogenic Protein Expression Is Not Different between Lean and Obese Individuals: A Potential Factor in Ceramide Accumulation.
94:5053-5061.
2009
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A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials of DHEA Treatment Effects on Quality of Life in Women with Adrenal Insufficiency.
94:3676-3681.
2009
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Association of Hematological Parameters with Insulin Resistance and β-Cell Dysfunction in Nondiabetic Subjects.
94:3824-3832.
2009
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The Relationship between Maternal and Umbilical Cord Androgen Levels and Polycystic Ovary Syndrome in Adolescence: A Prospective Cohort Study.
94:3714-3720.
2009
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Endocrine Treatment of Transsexual Persons:An Endocrine Society Clinical Practice Guideline.
94:3132-3154.
2009
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Drug-Induced Hypoglycemia: A Systematic Review.
94:741-745.
2009
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Evaluation and Management of Adult Hypoglycemic Disorders: An Endocrine Society Clinical Practice Guideline.
94:709-728.
2009
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Hypoglycemia with Intensive Insulin Therapy: A Systematic Review and Meta-Analyses of Randomized Trials of Continuous Subcutaneous Insulin InfusionVersusMultiple Daily Injections.
94:729-740.
2009
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Guidelines for the Management of Asymptomatic Primary Hyperparathyroidism: Summary Statement from the Third International Workshop.
94:335-339.
2009
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Surgery for Asymptomatic Primary Hyperparathyroidism: Proceedings of the Third International Workshop.
94:366-372.
2009
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The Diagnosis and Management of Asymptomatic Primary Hyperparathyroidism Revisited.
94:333-334.
2009
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Behavioral Interventions to Prevent Childhood Obesity: A Systematic Review and Metaanalyses of Randomized Trials.
93:4606-4615.
2008
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Prevention and Treatment of Pediatric Obesity: An Endocrine Society Clinical Practice Guideline Based on Expert Opinion.
93:4576-4599.
2008
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Treatment of Pediatric Obesity: A Systematic Review and Meta-Analysis of Randomized Trials.
93:4600-4605.
2008
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Quality of Reporting of Randomized Controlled Trials in General Endocrinology Literature.
93:3810-3816.
2008
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Case Detection, Diagnosis, and Treatment of Patients with Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline.
93:3266-3281.
2008
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Accuracy of Diagnostic Tests for Cushing’s Syndrome: A Systematic Review and Metaanalyses.
93:1553-1562.
2008
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The Diagnosis of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline.
93:1526-1540.
2008
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Antiandrogens for the Treatment of Hirsutism: A Systematic Review and Metaanalyses of Randomized Controlled Trials.
93:1153-1160.
2008
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Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline.
93:1105-1120.
2008
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Insulin Sensitizers for the Treatment of Hirsutism: A Systematic Review and Metaanalyses of Randomized Controlled Trials.
93:1135-1142.
2008
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A Case for Clarity, Consistency, and Helpfulness: State-of-the-Art Clinical Practice Guidelines in Endocrinology Using the Grading of Recommendations, Assessment, Development, and Evaluation System.
93:666-673.
2008
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Genetic Study of the Melanin-Concentrating Hormone Receptor 2 in Childhood and Adulthood Severe Obesity.
92:4403-4409.
2007
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Absence of Stabilizing Mutations of β-Catenin Encoded byCTNNB1Exon 3 in a Large Series of Sporadic Parathyroid Adenomas.
92:1564-1566.
2007
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Age at Menarche: Influences of Prenatal and Postnatal Growth.
92:46-50.
2007
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The Suppressor of Cytokine Signaling 3 Inhibits Leptin Activation of AMP-Kinase in Cultured Skeletal Muscle of Obese Humans.
91:3592-3597.
2006
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Adiponectin, Adiposity, and Insulin Resistance in Children and Adolescents.
91:2119-2125.
2006
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Testosterone Therapy in Adult Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline.
91:1995-2010.
2006
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Testosterone Use in Men and Its Effects on Bone Health. A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.
91:2011-2016.
2006
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Testosterone therapy in adult men with androgen deficiency syndromes: An endocrine society clinical practice guideline.
91:1995-2010.
2006
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TheINSVNTR Locus Does Not Associate with Smallness for Gestational Age (SGA) but Interacts with SGA to Increase Insulin Resistance in Young Adults.
91:2437-2440.
2006
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Efficacy of a Long-Acting Growth Hormone (GH) Preparation in Patients with Adult GH Deficiency.
90:6431-6440.
2005
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17β-Estradiol Supplementation Decreases Glucose Rate of Appearance and Disappearance with No Effect on Glycogen Utilization during Moderate Intensity Exercise in Men.
90:6218-6225.
2005
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Estrogen Supplementation Reduces Whole Body Leucine and Carbohydrate Oxidation and Increases Lipid Oxidation in Men during Endurance Exercise.
90:3592-3599.
2005
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Impact of Growth Hormone Supplementation on Adult Height in Turner Syndrome: Results of the Canadian Randomized Controlled Trial.
90:3360-3366.
2005
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Impaired Activation of AMP-Kinase and Fatty Acid Oxidation by Globular Adiponectin in Cultured Human Skeletal Muscle of Obese Type 2 Diabetics.
90:3665-3672.
2005
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Prevalence of Vitamin D Inadequacy among Postmenopausal North American Women Receiving Osteoporosis Therapy.
90:3215-3224.
2005
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Is Glutamate Decarboxylase 2 (GAD2) a Genetic Link between Low Birth Weight and Subsequent Development of Obesity in Children?.
90:2384-2390.
2005
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AMP-Activated Protein Kinase Is Not Down-Regulated in Human Skeletal Muscle of Obese Females.
89:4575-4580.
2004
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A Systematic Review and Metaanalysis of the Effectiveness of Radioactive Iodine Remnant Ablation for Well-Differentiated Thyroid Cancer.
89:3668-3676.
2004
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Alendronate in Primary Hyperparathyroidism: A Double-Blind, Randomized, Placebo-Controlled Trial.
89:3319-3325.
2004
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The Economic Implications of Three Biochemical Screening Algorithms for Pheochromocytoma.
89:2859-2866.
2004
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Growth Hormone (GH) Replacement Therapy in Adult-Onset GH Deficiency: Effects on Body Composition in Men and Women in a Double-Blind, Randomized, Placebo-Controlled Trial.
89:2048-2056.
2004
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Patients on Appropriate T4Replacement Are as Content as They Would Be on Any Thyroid Hormone.
89:2507-2507.
2004
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Authors’ Response: Dosage Recommendations for Combination Regimen of Thyroxine and 3,5,3′-Triiodothyronine.
89:1487-1487.
2004
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Dosage Recommendations for Combination Regimen of Thyroxine and 3,5,3′-Triiodothyronine.
89:1486-1487.
2004
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Does a Combination Regimen of Thyroxine (T4) and 3,5,3′-Triiodothyronine Improve Depressive Symptoms Better Than T4Alone in Patients with Hypothyroidism? Results of a Double-Blind, Randomized, Controlled Trial.
88:4551-4555.
2003
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A Comparison of Biochemical Tests for Pheochromocytoma: Measurement of Fractionated Plasma Metanephrines Compared with the Combination of 24-Hour Urinary Metanephrines and Catecholamines.
88:553-558.
2003
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Expression of Prostaglandin I2Synthase, but Not Prostaglandin E Synthase, Changes in Myometrium of Women at Term Pregnancy.
87:5274-5282.
2002
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A Randomized Double-Blind Trial to Compare the Efficacy of Teriparatide [Recombinant Human Parathyroid Hormone (1–34)] with Alendronate in Postmenopausal Women with Osteoporosis.
87:4528-4535.
2002
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Efficacy of Raloxifene on Vertebral Fracture Risk Reduction in Postmenopausal Women with Osteoporosis: Four-Year Results from a Randomized Clinical Trial.
87:3609-3617.
2002
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Efficacy of Raloxifene on Vertebral Fracture Risk Reduction in Postmenopausal Women with Osteoporosis: Four-Year Results from a Randomized Clinical Trial.
87:3609-3617.
2002
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Differential Changes in 15-Hydroxyprostaglandin Dehydrogenase and Prostaglandin H Synthase (Types I and II) in Human Pregnant Myometrium.
87:1345-1352.
2002
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Differential Changes in 15-Hydroxyprostaglandin Dehydrogenase and Prostaglandin H Synthase (Types I and II) in Human Pregnant Myometrium.
87:1345-1352.
2002
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Dermopathy of Graves’ Disease (Pretibial Myxedema): Long-Term Outcome.
87:438-446.
2002
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Sudden Enlargement of Local Recurrent Thyroid Tumor after Recombinant Human TSH Administration.
86:5148-5151.
2001
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Sudden Enlargement of Local Recurrent Thyroid Tumor after Recombinant Human TSH Administration.
86:5148-5151.
2001
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Efficacy of Ultrasound-Guided Fine-Needle Aspiration Biopsy in the Diagnosis of Complex Thyroid Nodules.
86:4089-4091.
2001
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Efficacy of Ultrasound-Guided Fine-Needle Aspiration Biopsy in the Diagnosis of Complex Thyroid Nodules.
86:4089-4091.
2001
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Oral Cholecystographic Agents and the Thyroid.
86:1853-1860.
2001
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Oral Cholecystographic Agents and the Thyroid.
86:1853-1860.
2001
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Leptin Production and Release in the Dually in VitroPerfused Human Placenta.
85:4298-4301.
2000
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Leptin Production and Release in the Duallyin VitroPerfused Human Placenta1.
85:4298-4301.
2000
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Regulatory effects of 1alpha,25-dihydroxyvitamin D3 on the cytokine production of human peripheral blood lymphocytes..
84:3739-3744.
1999
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Lack of Sex Difference in Cerebrospinal Fluid (CSF) Leptin Levels and Contribution of CSF/Plasma Ratios to Variations in Body Mass Index in Children.
84:3021-3024.
1999
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Lack of Sex Difference in Cerebrospinal Fluid (CSF) Leptin Levels and Contribution of CSF/Plasma Ratios to Variations in Body Mass Index in Children.
84:3021-3024.
1999
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Comparison of the Biochemical Responses to Human Parathyroid Hormone-(1-31)NH2 and hPTH-(1-34) in Healthy Humans.
84:2739-2743.
1999
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Comparison of the Biochemical Responses to Human Parathyroid Hormone-(1–31)NH2and hPTH-(1–34) in Healthy Humans1.
84:2739-2743.
1999
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Discordant Measures of Androgen-Binding Kinetics in Two Mutant Androgen Receptors Causing Mild or Partial Androgen Insensitivity, Respectively.
84:805-810.
1999
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Discordant Measures of Androgen-Binding Kinetics in Two Mutant Androgen Receptors Causing Mild or Partial Androgen Insensitivity, Respectively1.
84:805-810.
1999
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Troglitazone monotherapy improves glycemic control in patients with type 2 diabetes mellitus: a randomized, controlled study. The Troglitazone Study Group..
83:3169-3176.
1998
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Development of a health-related quality-of-life questionnaire (PCOSQ) for women with polycystic ovary syndrome (PCOS)..
83:1976-1987.
1998
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Treatment of estrogen deficiency symptoms in women surviving breast cancer.
83:1993-2000.
1998
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Cloning and Characterization of the Promoter Regions of the Human Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Gene: Analysis of Deoxyribonucleic Acid from Normal Subjects and Patients with Pseudohypoparathyroidism Type 1b.
82:1031-1040.
1997
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A Randomized Controlled Trial to Compare the Efficacy of Cyclical Parathyroid Hormone Versus Cyclical Parathyroid Hormone and Sequential Calcitonin to Improve Bone Mass in Postmenopausal Women with Osteoporosis.
82:620-628.
1997
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A Randomized Controlled Trial to Compare the Efficacy of Cyclical Parathyroid HormoneVersusCyclical Parathyroid Hormone and Sequential Calcitonin to Improve Bone Mass in Postmenopausal Women with Osteoporosis1.
82:620-628.
1997
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Late luteal phase dysphoric disorder and the thyroid axis revisited.
81:2280-2284.
1996
-
Late luteal phase dysphoric disorder and the thyroid axis revisited..
81:2280-2284.
1996
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Mortality in Canadian children with growth hormone (GH) deficiency receiving GH therapy 1967-1992. The Canadian Growth Hormone Advisory Committee.
81:1693-1696.
1996
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2-[125I]iodomelatonin-binding sites in the human kidney and the effect of guanosine 5'-O-(3-thiotriphosphate)..
80:1560-1565.
1995
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Melatonin receptors on human granulosa cell membranes.
80:1747-1749.
1995
-
Melatonin receptors on human granulosa cell membranes..
80:1747-1749.
1995
-
Photoperiod-driven changes in reproductive function in male rhesus monkeys..
74:1068-1074.
1992
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Concordant Graves' Disease after Bone Marrow Transplantation: Implications for Pathogenesis.
72:837-840.
1991
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Daily Cortisol Production Rate in Man Determined by Stable Isotope Dilution/Mass Spectrometry.
72:39-45.
1991
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Inhibin and Estradiol Responses to Ovarian Hyperstimultion: Effects of Age and Predictive Value forin VitroFertilization Outcome.
70:358-364.
1990
-
Occult Ovarian Failure: A Syndrome of Infertility, Regular Menses, and Elevated Follicle-Stimulating Hormone Concentrations.
67:1190-1194.
1988
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Changing Osteocalcin Concentrations During Pregnancy and Lactation: Implications for Maternal Mineral Metabolism*.
65:290-294.
1987
-
Evidence for Leydig Cell Dysfunction in Infertile Men with a Selective Increase in Plasma Follicle-Stimulating Hormone*.
64:1194-1198.
1987
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Separate Induction of MHC and Thyroid Microsomal Antigen (McAg) Expression on Thyroid Cell Monolayers: Enhancement of Lectin-Induced McAg Expression by Interferon-γ*.
64:1302-1308.
1987
-
Gonadotropin-Independent Precocious Puberty (“Testotoxicosis”): Influence of Maturational Status on Response to Ketoconazole.
64:328-333.
1987
-
Pharmacokinetic Characteristics of the Gonadotropin-Releasing Hormone Analog D-Ser(TBU)-6EA-10Luteinizing Hormone-Releasing Hormone (Buserelin) after Subcutaneous and Intranasal Administration in Children with Central Precocious Puberty.
63:1065-1070.
1986
-
Thyrocyte HLA-DR Expression and Interferon-γProduction in Autoimmune Thyroid Disease*.
63:695-708.
1986
-
Intranasal and Subcutaneous Treatment of Central Precocious Puberty in Both Sexes with a Long-Acting Analog of Luteinizing Hormone-Releasing Hormone*.
58:966-972.
1984
-
Corticotropin-Releasing Factor: Pharmacokinetics in Man.
58:192-196.
1984
-
Three-Year Changes in Bone Mineral Mass of Postmenopausal Osteoporotic Patients Based on Neutron Activation Analysis of the Central Third of the Skeleton*.
52:751-758.
1981
-
Altered Glucoregulatory Response to Physiological Infusions of Epinephrine and Glucagon in Hyperthyroidism*.
51:972-977.
1980
-
Glucoregulatory Response to Insulin-Induced Hypoglycemia in Laennec’s Cirrhosis.
46:778-783.
1978
-
Characteristics of Antibody Produced During Chronic Treatment with LHRH.
44:784-790.
1977
-
EFFECT OF CARBIDOPA ON PROLACTIN, GROWTH HORMONE AND CORTISOL SECRETION IN MAN.
43:236-239.
1976
-
STIMULATION OF RHESUS MONKEY GH RELEASE: ARGININE VS PLASMA VOLUME EXPANSION1.
42:169-172.
1976
-
THE SECRETION AND DISPOSITION OF CORTISOL DURING PREGNANCY*.
18:1076-1092.
1958
-
A CASE OF MASCULINIZING OVARIAN TUMOR: USE OF CORTICOSTEROID INHIBITION TEST IN DIAGNOSIS.
18:794-797.
1958
-
STUDIES ON THE ORIGIN OF ALDOSTERONE DURING HUMAN PREGNANCY*.
18:222-225.
1958
-
Medical Management of Asymptomatic Primary Hyperparathyroidism: Proceedings of the Third International Workshop
2009
-
Quantification of the soluble leptin receptor in human blood by ligand-mediated immunofunctional assay.
2002
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