Current Controlled Trials in Cardiovascular Medicine Trials
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Overview
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A randomised controlled trial assessing the use of citalopram, sertraline, fluoxetine and mirtazapine in preventing relapse in primary care patients who are taking long-term maintenance antidepressants (ANTLER: ANTidepressants to prevent reLapse in dEpRession): study protocol for a randomised controlled trial.
20:319.
2019
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Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial.
20:532.
2019
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Rationale and methods of an Evaluation of the Effectiveness of the Community Paramedicine at Home (CP@home) program for frequent users of emergency medical services in multiple Ontario regions: a study protocol for a randomized controlled trial.
20:75.
2019
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What happens to intimate partner violence studies registered on clinicaltrials.gov? A systematic review of a clinical trials registry.
20:288.
2019
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Multimorbidity risk assessment in adolescents and adults with cerebral palsy: a protocol for establishing a core outcome set for clinical research and practice..
20:176.
2019
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7 versus 14 days of antibiotic treatment for critically ill patients with bloodstream infection: a pilot randomized clinical trial.
19:111.
2018
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Exploring factors associated with views on sharing of certain interim trial result measures by the data safety monitoring board (DSMB) with non-DSMB members.
19:621.
2018
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FIT for FUNCTION: study protocol for a randomized controlled trial.
19:39.
2018
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Femoroacetabular Impingement Randomised controlled Trial (FIRST) - a multi-centre randomized controlled trial comparing arthroscopic lavage and arthroscopic osteochondroplasty on patient important outcomes and quality of life in the treatment of young adult (18–50 years) femoroacetabular impingement: a statistical analysis plan.
19:588.
2018
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Intrauterine resuscitation during the second stage of term labour by maternal hyperoxygenation versus conventional care: study protocol for a randomised controlled trial (INTEREST O2).
19:195.
2018
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Outcome Measures in Rheumatology - Interventions for medication Adherence (OMERACT-Adherence) Core Domain Set for Trials of Interventions for Medication Adherence in Rheumatology: 5 Phase Study Protocol.
19:204.
2018
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Prevention of Infections in Cardiac Surgery study (PICS): study protocol for a pragmatic cluster-randomized factorial crossover pilot trial.
19:688.
2018
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Short-course antimicrobial therapy for paediatric respiratory infections (SAFER): study protocol for a randomized controlled trial.
19:83.
2018
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Statistical analysis plan for a cluster-randomized crossover trial comparing the effectiveness and safety of a flexible family visitation model for delirium prevention in adult intensive care units (the ICU Visits Study).
19:636.
2018
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Statistical analysis plan for the Pneumatic CompREssion for PreVENting Venous Thromboembolism (PREVENT) trial: a study protocol for a randomized controlled trial.
19:182.
2018
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Structured diet and exercise guidance in pregnancy to improve health in women and their offspring: study protocol for the Be Healthy in Pregnancy (BHIP) randomized controlled trial.
19:691.
2018
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Survey of professional views on sharing interim results by the Data Safety Monitoring Board (DSMB): what to share, with whom and why.
19:281.
2018
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The Classroom Communication Resource (CCR) intervention to change peer’s attitudes towards children who stutter (CWS): study protocol for a randomised controlled trial.
19:43.
2018
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Correction to: Intrauterine resuscitation during the second stage of term labour by maternal hyperoxygenation versus conventional care: study protocol for a randomised controlled trial (INTEREST O2).
19:580.
2018
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A multi-centre randomised trial to compare the effectiveness of geriatrician-led admission avoidance hospital at home versus inpatient admission.
18:491.
2017
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Barriers and facilitators to healthcare professional behaviour change in clinical trials using the Theoretical Domains Framework: a case study of a trial of individualized temperature-reduced haemodialysis.
18:227.
2017
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Challenges to complete and useful data sharing.
18:71.
2017
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Determining the impact of a new physiotherapist-led primary care model for back pain: protocol for a pilot cluster randomized controlled trial.
18:526.
2017
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Feasibility of a Systematic, Comprehensive, One-to-One Training (SCOOT) program for new scooter users: study protocol for a randomized control trial.
18:235.
2017
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General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial.
18:442.
2017
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Interactive weekly mobile phone text messaging plus motivational interviewing in promotion of breastfeeding among women living with HIV in South Africa: study protocol for a randomized controlled trial.
18:331.
2017
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Intrapleural Dornase and Tissue Plasminogen Activator in pediatric empyema (DTPA): a study protocol for a randomized controlled trial.
18:293.
2017
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Promoting deceased organ and tissue donation registration in family physician waiting rooms (RegisterNow-1 trial): study protocol for a pragmatic, stepped-wedge, cluster randomized controlled registry.
18:610.
2017
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Sharing interim trial results by the Data Safety Monitoring Board with those responsible for the trial’s conduct and progress: a narrative review.
18:120.
2017
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The ACHRU-CPP versus usual care for older adults with type-2 diabetes and multiple chronic conditions and their family caregivers: study protocol for a randomized controlled trial.
18:55.
2017
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The SYGMA programme of phase 3 trials to evaluate the efficacy and safety of budesonide/formoterol given ‘as needed’ in mild asthma: study protocols for two randomised controlled trials.
18:12.
2017
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The effectiveness of a Supported Self-management task-shifting intervention for adult depression in Vietnam communities: study protocol for a randomized controlled trial.
18:209.
2017
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A patient decision aid for antidepressant use in pregnancy: study protocol for a randomized controlled trial.
17:110.
2016
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A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial.
17:556.
2016
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Accounting for treatment by center interaction in sample size determinations and the use of surrogate outcomes in the pessary for the prevention of preterm birth trial: a simulation study.
17:310.
2016
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Efficacy of ultra-micronized palmitoylethanolamide (um-PEA) in geriatric patients with chronic pain: study protocol for a series of N-of-1 randomized trials.
17:369.
2016
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Erratum to: Thromboprophylaxis using combined intermittent pneumatic compression and pharmacologic prophylaxis versus pharmacologic prophylaxis alone in critically ill patients: study protocol for a randomized controlled trial.
17:420.
2016
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Magnesium nebulization utilization in management of pediatric asthma (MagNUM PA) trial: study protocol for a randomized controlled trial.
17:261.
2016
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Oral steroids for the resolution of otitis media with effusion (OME) in children (OSTRICH): study protocol for a randomised controlled trial.
17:115.
2016
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Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial—PROSPECT: a pilot trial.
17:377.
2016
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Steroids in fluid and/or vasoactive infusion dependent pediatric shock: study protocol for a randomized controlled trial.
17:238.
2016
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The ethics of future trials: qualitative analysis of physicians’ decision making.
17:12.
2016
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Thromboprophylaxis using combined intermittent pneumatic compression and pharmacologic prophylaxis versus pharmacologic prophylaxis alone in critically ill patients: study protocol for a randomized controlled trial.
17:390.
2016
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A practical application of a novel software solution to aid identification of research participants in primary care - the CREAM study (children with eczema antibiotic management study).
16:P230-P230.
2015
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Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): study protocol for a pilot randomized controlled trial.
16:173.
2015
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Can an antimicrobial stewardship program reduce length of stay of immune-competent adult patients admitted to hospital with diagnosis of community-acquired pneumonia? Study protocol for pragmatic controlled non-randomized clinical study.
16:355.
2015
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Chronic pain self-management support with pain science education and exercise (COMMENCE): study protocol for a randomized controlled trial.
16:462.
2015
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Decision aid on radioactive iodine treatment for early stage papillary thyroid cancer: update to study protocol with follow-up extension.
16:302.
2015
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Effectiveness and cost-effectiveness of cognitive adaptation training as a nursing intervention in long-term residential patients with severe mental illness: study protocol for a randomized controlled trial.
16:49.
2015
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Effectiveness of pharmaceutical care at discharge in the emergency department: study protocol of a randomized controlled trial.
16:60.
2015
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Evaluating processes of care and outcomes of children in hospital (EPOCH): study protocol for a randomized controlled trial.
16:245.
2015
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Evaluation of multisystemic therapy pilot services in Services for Teens Engaging in Problem Sexual Behaviour (STEPS-B): study protocol for a randomized controlled trial.
16:492.
2015
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Key stakeholder perceptions about consent to participate in acute illness research: a rapid, systematic review to inform epi/pandemic research preparedness.
16:591.
2015
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Logistic, ethical, and political dimensions of stepped wedge trials: critical review and case studies.
16:351.
2015
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Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial.
16:300.
2015
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Nortriptyline in knee osteoarthritis (NortIKA Study): study protocol for a randomised controlled trial.
16:448.
2015
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Opioid substitution and antagonist therapy trials exclude the common addiction patient: a systematic review and analysis of eligibility criteria.
16:475.
2015
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Preconditioning Shields Against Vascular Events in Surgery (SAVES), a multicentre feasibility trial of preconditioning against adverse events in major vascular surgery: study protocol for a randomised control trial.
16:185.
2015
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Recruitment to oral steroids for the resolution of otitis media with effusion in children (OSTRICH) study: challenges of a randomised controlled trial in secondary care sites across Wales and England.
16:P119-P119.
2015
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Reducing the confusion and controversies around pragmatic trials: using the Cardiovascular Health Awareness Program (CHAP) trial as an illustrative example.
16:387.
2015
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Setting up a clinical trial in care homes: challenges encountered and recommendations for future research practice.
16:P198-P198.
2015
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Strategic use of new generation antidepressants for depression: SUN(^_^) D protocol update and statistical analysis plan.
16:459.
2015
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Successful knowledge translation intervention in long-term care: final results from the vitamin D and osteoporosis study (ViDOS) pilot cluster randomized controlled trial.
16:214.
2015
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Sustained Aeration of Infant Lungs (SAIL) trial: study protocol for a randomized controlled trial.
16:95.
2015
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The impact of a delayed consent model on trial recruitment - the cream study (children with eczema antibiotic management study).
16:P199-P199.
2015
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Using an adaptive trial design for an infectious disease in primacy care - challenges in the design and set-up stages.
16:P211-P211.
2015
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Virtual colonoscopy, optical colonoscopy, or fecal occult blood testing for colorectal cancer screening: results of a pilot randomized controlled trial.
16:296.
2015
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Comparison between the standard and a new alternative format of the Summary-of-Findings tables in Cochrane review users: study protocol for a randomized controlled trial.
16:164-164.
2015
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A double-blind, randomized controlled trial to compare the effect of biannual peripheral magnetic resonance imaging, radiography and standard of care disease progression monitoring on pharmacotherapeutic escalation in rheumatoid and undifferentiated inflammatory arthritis: study protocol for a randomized controlled trial.
15:268.
2014
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Accounting for center in the Early External Cephalic Version trials: an empirical comparison of statistical methods to adjust for center in a multicenter trial with binary outcomes.
15:377.
2014
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Building clinical trial priorities at the University of Rwanda.
15:467.
2014
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Comparing the feasibility, acceptability, clinical-, and cost-effectiveness of mental health e-screening to paper-based screening on the detection of depression, anxiety, and psychosocial risk in pregnant women: a study protocol of a randomized, parallel-group, superiority trial.
15:3.
2014
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Corticosteroid treatment for community-acquired pneumonia - the STEP trial: study protocol for a randomized controlled trial.
15:257.
2014
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Economic evaluation of the prophylaxis for thromboembolism in critical care trial (E-PROTECT): study protocol for a randomized controlled trial.
15:502.
2014
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Furosemide and albumin for diuresis of edema (FADE): a study protocol for a randomized controlled trial.
15:222.
2014
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Impact of emergency department probiotic treatment of pediatric gastroenteritis: study protocol for the PROGUT (Probiotic Regimen for Outpatient Gastroenteritis Utility of Treatment) randomized controlled trial.
15:170.
2014
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Sleep to lower elevated blood pressure: study protocol for a randomized controlled trial.
15:393.
2014
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SodiUm SeleniTe Adminstration IN Cardiac Surgery (SUSTAIN CSX-trial): study design of an international multicenter randomized double-blinded controlled trial of high dose sodium-selenite administration in high-risk cardiac surgical patients.
15:339.
2014
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Study protocol for a randomized, controlled, superiority trial comparing the clinical and cost- effectiveness of integrated online mental health assessment-referral-care in pregnancy to usual prenatal care on prenatal and postnatal mental health and infant health and development: the Integrated Maternal Psychosocial Assessment to Care Trial (IMPACT).
15:72.
2014
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Trial to re-evaluate ultrasound in the treatment of tibial fractures (TRUST): a multicenter randomized pilot study.
15:206.
2014
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Methodological survey of designed uneven randomization trials (DU-RANDOM): a protocol.
15:33-33.
2014
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Recruitment to diagnosis of urinary tract infections in young children (DUTY) study: an evaluation of the successful methods used in a primary care, prospective cohort study.
14:P37-P37.
2013
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Consent, including advanced consent, of older adults to research in care homes: a qualitative study of stakeholders’ views in South Wales.
14:247-247.
2013
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Development and feasibility testing of decision support for patients who are candidates for a prophylactic implantable defibrillator: a study protocol for a pilot randomized controlled trial.
14:346-346.
2013
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Feasibility of the Enhancing Participation In the Community by improving Wheelchair Skills (EPIC Wheels) program: study protocol for a randomized controlled trial.
14:350-350.
2013
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HIV prevention in favour of the choice-disabled in southern Africa: study protocol for a randomised controlled trial.
14:274-274.
2013
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Initiation and continuation of randomized trials after the publication of a trial stopped early for benefit asking the same study question: STOPIT-3 study design.
14:335-335.
2013
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Randomized controlled trial comparing telephone and mail follow-up for recruitment of participants into a clinical trial of colorectal cancer screening.
14:40-40.
2013
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Supporting the improvement and management of prescribing for urinary tract infections (SIMPle): protocol for a cluster randomized trial.
14:441-441.
2013
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Assessing the effectiveness of ‘pulse radiofrequency treatment of dorsal root ganglion’ in patients with chronic lumbar radicular pain: study protocol for a randomized control trial.
13:52.
2012
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Central coordination as an alternative for local coordination in a multicenter randomized controlled trial: the FAITH trial experience.
13:5.
2012
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Comparing the effectiveness of copper intrauterine devices available in Canada. Is FlexiT non-inferior to NovaT when inserted immediately after first-trimester abortion? Study protocol for a randomized controlled trial.
13:147.
2012
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Rapid, easy, and cheap randomization: prospective evaluation in a study cohort.
13:90.
2012
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Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial.
13.
2012
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A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial.
12:70.
2011
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A prospective, double-blind, randomized, controlled clinical trial comparing standard wound care with adjunctive hyperbaric oxygen therapy (HBOT) to standard wound care only for the treatment of chronic, non-healing ulcers of the lower limb in patients with diabetes mellitus: a study protocol.
12:69.
2011
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Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group.
12:48.
2011
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Does clinical equipoise apply to cluster randomized trials in health research?.
12:118.
2011
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Effect of selenium supplementation on CD4 T-cell recovery, viral suppression, morbidity and quality of life of HIV-infected patients in Rwanda: study protocol for a randomized controlled trial.
12:192.
2011
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Ethical issues posed by cluster randomized trials in health research.
12:100.
2011
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Exploring the ethical and practical challenges of conducting clinical trials in care home settings.
12:A38-A38.
2011
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Immediate vs. delayed insertion of intrauterine contraception after second trimester abortion: study protocol for a randomized controlled trial.
12:149.
2011
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Investigator experiences with financial conflicts of interest in clinical trials.
12:9.
2011
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The cameroon mobile phone sms (CAMPS) trial: a protocol for a randomized controlled trial of mobile phone text messaging versus usual care for improving adherence to highly active anti-retroviral therapy.
12:5.
2011
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The challenges and opportunities of conducting a clinical trial in a low resource setting: The case of the Cameroon mobile phone SMS (CAMPS) trial, an investigator initiated trial.
12:145.
2011
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The impact of clinical data on the evaluation of tibial fracture healing.
12:237.
2011
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When is informed consent required in cluster randomized trials in health research?.
12:202.
2011
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Who is the research subject in cluster randomized trials in health research?.
12:183.
2011
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Decision aid on radioactive iodine treatment for early stage papillary thyroid cancer - a randomized controlled trial.
11:81.
2010
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Design, analysis, and presentation of crossover trials.
10:27.
2009
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Ethical and policy issues in cluster randomized trials: rationale and design of a mixed methods research study.
10:61.
2009
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Incorporating multiple interventions in meta-analysis: an evaluation of the mixed treatment comparison with the adjusted indirect comparison.
10:86.
2009
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The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol.
10:87.
2009
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Wean Earlier and Automatically with New technology (the WEAN study): a protocol of a multicentre, pilot randomized controlled trial.
10:81.
2009
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LOST to follow-up Information in Trials (LOST-IT): a protocol on the potential impact.
10:40-40.
2009
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Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2).
10:49-49.
2009
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Subgroup Analysis of Trials Is Rarely Easy (SATIRE): a study protocol for a systematic review to characterize the analysis, reporting, and claim of subgroup effects in randomized trials.
10:101-101.
2009
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Community-based randomised controlled trial evaluating falls and osteoporosis risk management strategies.
9:62.
2008
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Reporting of noninferiority and equivalence randomized trials for major prostaglandins: A systematic survey of the ophthalmology literature.
9:69.
2008
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What constitutes a "clinical trial"?: A survey of oncology professionals.
9:12.
2008
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Dose response of ACE inhibitors: implications of the SECURE trial..
2:155-155.
2001
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Considerations in designing equity-relevant clinical trials
2017
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Mediation analysis to explore causal mechanisms in trials of complex interventions
2017
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On synthesis evidence from explanatory and pragmatic trials: a comparison of meta-analytic methods
2017
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Pilot and feasibility studies: a systematic review of studies conducted at the population health research institute
2017
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Statistical considerations for analyzing multiplex biomarker data from prospective studies
2017
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Defining feasibility and pilot studies in preparation for randomised controlled trials: using consensus methods and validation to develop a conceptual framework
2015
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EBRNetwork – a call to action for evidence-based research
2015
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Improving the reporting of randomised pilot and feasibility studies: a consort statement extension
2015
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