selected scholarly activity
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books
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chapters
- Clinical Applications of External Evidence. 1133-1137. 2009
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conferences
- Altered and distinct cardioautonomic responses to esophageal stimulation (ES) in patients with GERD or with non-cardiac chest pain (NCCP). Gastroenterology. A632-A632. 2001
- Cortical evaked petential response (EP) to esophageal stimulation (ES) in healthy controls and patients with GERD or non-cardiac chest pain (NCCP). Gastroenterology. A222-A222. 2001
- A quantitative method for defining scar with F-18-FDG PET predicts the degree of recovery of LV function post-revascularization. Circulation. 724-724. 2000
- The extent of ischemic and non-ischemic viable tissue predicts the degree of recovery of LV dysfunction post-revascularization. Journal of the American College of Cardiology. 428A-428A. 2000
- Assessment of autonomic pathways through esophageal stimulation. Computers in Cardiology. 805-808. 2000
- Beta blocker therapy improves cardiac efficiency in patients with left ventricle dysfunction. Circulation. 26-26. 1999
- Altered cerebral processing of perceived esophageal stimuli in non-cardiac chest pain (NCCP).. Gastroenterology. A1093-A1093. 1999
- The autonomic response to esophageal stimulation is enhanced by rhythmic stimulation and decreased by irregular stimulation.. Gastroenterology. A1094-A1094. 1999
- The congnitive processing associated with perception of esophageal stimulation is enhanced in patients with non-cardiac chest pain (NCCP). Gastroenterology. A1008-A1008. 1999
- The cortical evoked response associated with perception of an unpredictable esophageal stimulus is greater than with a regularly occurring stimulus.. Gastroenterology. A1008-A1008. 1999
- Does the patient with severe LV dysfunction have impaired cardiac efficiency?. Circulation. 279-279. 1998
- Functional disorders of the upper gastrointestinal tract. New concepts. GASTROENTEROLOGY AND HEPATOLOGY: THE NEXT MILLENIUM. 105-110. 1998
- State space modeling of cardiovascular regulation. Computers in Cardiology. 497-500. 1998
- Central nervous system mediated neurocardiac effects of visceral sensory afferents in humans. Circulation. 1467-1467. 1997
- Time dependant changes in myocardial blood flow and sympathetic reinnervation post acute myocardial infarction. Circulation. 3012-3012. 1997
- The magnitude of autonomic responses to esophageal electrical stimulation is modulated by cortical perception. Gut. A25-A25. 1997
- Barostat-controlled, rectal distention modifies heart rate variability in healthy subjects.. Gastroenterology. A693-A693. 1997
- Patterns of autonomic dysregulation in congestive heart failure: Relationship with LV function and neurohumoral activation. Circulation. 1909-1909. 1996
- A low resting vagal tone predicts response to acid perfusion in patients with esophageal symptoms.. Gastroenterology. A762-A762. 1996
- Autonomic response to esophageal acid perfusion in patients with esophageal symptoms.. Gastroenterology. A762-A762. 1996
- Barostat-controlled esophageal balloon distension produces a pressure-dependent heart rate decrease in healthy subjects. Gastroenterology. A624-A624. 1996
- Low pressure, unperceived, barostat-controlled esophageal distension decreases heart rate in healthy subjects. Gastroenterology. A625-A625. 1996
- Time-frequency analysis of heart rate variability signals in patients with autonomic dysfunction. Proceedings of Third International Symposium on Time-Frequency and Time-Scale Analysis (TFTS-96). 373-376. 1996
- Heart rate variability in gastroenterological diagnosis. Computers in Cardiology. 289-291. 1995
- HEART-RATE-VARIABILITY AND DEPRESSION - A LINKAGE. Circulation. 591-591. 1994
- CARDIAC EFFECTS OF ESOPHAGEAL STIMULATION IN HEALTHY-VOLUNTEERS. Gastroenterology. A579-A579. 1994
- SILENT ISCHEMIA IN SURVIVORS OF ACUTE MYOCARDIAL-INFARCTION (SISAMI STUDY) - SUPERIOR PROGNOSTIC VALUE OF HOLTER MONITORING EARLY POST MYOCARDIAL-INFARCTION. Circulation. 258-258. 1993
- REGIONAL DISTRIBUTION AND WASHOUT OF 6-[F-18] FLUORODOPAMINE AS A MEASURE OF CARDIAC SYMPATHETIC ACTIVITY IN MAN. Circulation. 247-247. 1992
- DETERMINISTIC CHAOS IN HUMAN HEART-RATE-VARIABILITY AT SIMULATED EXTREME ALTITUDE. The FASEB Journal. A1528-A1528. 1992
- Effects of vagal electrical stimulation on the heart rate power spectra in humans. Proceedings Computers in Cardiology. 399-402. 1992
- Evidence for deterministic chaos in heart rhythms. Proceedings Computers in Cardiology. 459-461. 1992
- ON THE PROGNOSIS OF PATIENTS ADMITTED TO CORONARY-CARE UNIT WITH CHEST PAIN NYD. Clinical Research. A372-A372. 1991
- Clinical Applications Of Heart Rate Variability Power Spectra. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 656-657. 1991
- CIRCADIAN-RHYTHMS IN ACUTE MYOCARDIAL-INFARCTION (AMI). Circulation. 516-516. 1990
- EVENTUAL DIAGNOSES AND OUTCOME IN PATIENTS DISCHARGED FROM CORONARY-CARE WITH UNDIAGNOSED CHEST PAIN. Gut. A1446-A1446. 1989
- CHEST PAIN NOT YET DIAGNOSED ON LEAVING THE CORONARY-CARE UNIT - THEIR DIAGNOSES AND OUTCOMES. Clinical Research. A593-A593. 1989
- HEART RATE VARIABILITY POWER SPECTRA IN NORMAL SUBJECTS AND IN PATIENTS WITH CARDIAC DYSFUNCTION.. IEEE/Engineering in Medicine and Biology Society Annual Conference. 523-524. 1987
- PREVALENCE OF LATE VENTRICULAR ARRHYTHMIA POSTMYOCARDIAL INFARCTION IN A DEFINED COMMUNITY. Circulation. 394-394. 1987
- IS DIGOXIN OF BENEFIT TO HEART-FAILURE PATIENTS IN SINUS RHYTHM. Clinical Research. A346-A346. 1987
- IS DIGOXIN OF BENEFIT TO HEART-FAILURE PATIENTS IN SINUS RHYTHM. Clinical and Investigative Medicine. B77-B77. 1987
- CLINICAL CARDIAC MECHANICS - SIMPLISTIC FORMULATIONS OF SEGMENTAL PROPERTIES AND COMPENSATORY MECHANISMS.. Modeling and Simulation, Proceedings of the Annual Pittsburgh Conference. 969-976. 1983
- VAGAL EFFERENT DEPRESSION OF SEGMENTAL CONTRACTILITY DUE TO ACUTE POSTERIOR WALL ISCHEMIA. Circulation. 150-150. 1980
- AFTERLOAD AND REFLEX REGULATION OF CARDIAC RESPONSE TO MYOCARDIAL ISCHEMIA. Circulation. 252-252. 1978
- CK KINETICS IN LIGATION, REPERFUSION AND EMBOLIZATION MYOCARDIAL-INFARCTION IN DOG. Clinical Research. A831-A831. 1978
- ROLE OF AUTONOMIC REFLEXES DURING ACUTE CORONARY-OCCLUSION. Clinical Research. A833-A833. 1978
- EFFECTS OF DECREASED HEMOGLOBIN-OXYGEN AFFINITY ON CORONARY VASCULAR REACTIVITY IN NORMAL AND ISCHEMIC DOG HEARTS. Clinical Research. A673-A673. 1977
- EVIDENCE THAT AFTERLOAD PRE-DETERMINES CHANGE IN STROKE VOLUME FOLLOWING ACUTE CORONARY-OCCLUSION. Clinical Research. A670-A670. 1977
- INFARCT SIZE FROM SERIAL CPK - VARIABILITY OF SERUM ENTRY RATIO WITH INFARCT SIZE AND MODEL. Circulation. 70-70. 1977
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journal articles
- The Challenge of Timing Surgery in a Complex Case of Endocarditis. Canadian Journal of Cardiology. 29:126-129. 2013
- Appropriate medical management and close follow-up for adherence and efficacy. New England Journal of Medicine. 357:1763. 2007
- Clinical decisions. Management of stable coronary disease.. New England Journal of Medicine. 357:1762-1766. 2007
- Management of Stable Coronary Disease. New England Journal of Medicine. 357:1762-1766. 2007
- Vagal Afferent Stimulation as a Cardioprotective Strategy? Introducing the Concept. Annals of Noninvasive Electrocardiology. 10:441-446. 2005
- Evaluation of outcome and cost-effectiveness using an FDG PET-guided approach to management of patients with coronary disease and severe left ventricular dysfunction (PARR-2): rationale, design, and methods. Contemporary Clinical Trials. 24:776-794. 2003
- Coronary artery disease, inflammation and the ghost of John Hunter. Inflammopharmacology. 11:195-201. 2003
- Cardiac resynchronization and myocardial oxidative metabolism - Response. Circulation. 107:E220-E220. 2003
- Effect of Cardiac Resynchronization on Myocardial Efficiency and Regional Oxidative Metabolism. Circulation. 107:28-31. 2003
- Positron emission tomography and recovery following revascularization (PARR-1): the importance of scar and the development of a prediction rule for the degree of recovery of left ventricular function. Journal of the American College of Cardiology. 40:1735-1743. 2002
- Cardiac autonomic function and oesophageal acid sensitivity in patients with non-cardiac chest pain. Gut. 49:706-712. 2001
- Effect of sertraline on the recovery rate of cardiac autonomic function in depressed patients after acute myocardial infarction. American Heart Journal. 142:617-623. 2001
- Effect of sertraline on the recovery rate of cardiac autonomic function in depressed patients after acute myocardial infarction. American Heart Journal. 142:617-623. 2001
- Afferent vagal modulation. Autonomic Neuroscience: Basic and Clinical. 90:35-40. 2001
- Abnormal cerebral processing of oesophageal stimuli in patients with noncardiac chest pain (NCCP). Neurogastroenterology and Motility. 12:555-565. 2000
- Hidden rhythms in the heart rate record: a primer on neurocardiology. Clinical and Investigative Medicine. 23:339-346. 2000
- Hidden rhythms in the heart rate record: a primer on neurocardiology.. Clinical and Investigative Medicine. 23:387-394. 2000
- The Effects of β 1 -Blockade on Oxidative Metabolism and the Metabolic Cost of Ventricular Work in Patients With Left Ventricular Dysfunction. Circulation. 102:2070-2075. 2000
- The effect of sertraline on Autonomic Nervous System (ANS) regulation in post myocardial infarction. Heart. 83. 2000
- Effects of Metoprolol CR in Patients With Ischemic and Dilated Cardiomyopathy. Circulation. 101:378-384. 2000
- Effects of Esophageal Stimulation in Healthy Subjects. Critical Reviews in Biomedical Engineering. 28:81-86. 2000
- Effects of Esophageal Stimulation in Patients With Functional Disorders of the Gastrointestinal Tract. Critical Reviews in Biomedical Engineering. 28:87-93. 2000
- Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. The Lancet. 355:253-259. 2000
- Recovery rates of regional sympathetic reinnervation and myocardial blood flow after acute myocardial infarction. American Heart Journal. 137:863-869. 1999
- Effects of esophageal stimulation in healthy subjects. Critical Reviews in Biomedical Engineering. 26:307-308. 1998
- Effects of esophageal stimulation in patients with functional disorders of the gastrointestinal tract. Critical Reviews in Biomedical Engineering. 26:308-309. 1998
- Neurocardiac and cerebral responses evoked by esophageal vago-afferent stimulation in humans: effect of varying intensities. Cardioscience. 40:591-599. 1998
- Assessment of the visceral afferent and autonomic pathways in response to esophageal stimulation in control subjects and in patients with diabetes.. Clinical and Investigative Medicine. 21:100-113. 1998
- The cerebral response to electrical stimuli in the oesophagus is altered by increasing stimulus frequencies. Neurogastroenterology and Motility. 9:129-139. 1997
- Can Nitrogen-13 Ammonia Kinetic Modeling Define Myocardial Viability Independent of Fluorine-18 Fluorodeoxyglucose?. Journal of the American College of Cardiology. 29:537-543. 1997
- Neurocardiac response to esophageal electric stimulation in humans: Effects of varying stimulation frequencies. American Journal of Physiology. Regulatory Integrative and Comparative Physiology. 272:R896-R901. 1997
- Neurocardiac response to esophageal electric stimulation in humans: effects of varying stimulation frequencies. American Journal of Physiology. 272:R896-R901. 1997
- Modulation of Neurocardiac Function by Oesophageal Stimulation in Humans. Clinical Science. 92:167-174. 1997
- Outcome of patients discharged from a coronary care unit with a diagnosis of "chest pain not yet diagnosed".. CANADIAN MEDICAL ASSOCIATION JOURNAL. 155:541-546. 1996
- Double blind placebo controlled trial of short term transdermal scopolamine on heart rate variability in patients with chronic heart failure.. Heart. 76:137-143. 1996
- Heart Rate Variability. Circulation. 93:1043-1065. 1996
- Heart rate variability: Standards of measurement, physiological interpretation, and clinical use. European Heart Journal. 17:354-381. 1996
- The HOPE (Heart Outcomes Prevention Evaluation) Study: the design of a large, simple randomized trial of an angiotensin-converting enzyme inhibitor (ramipril) and vitamin E in patients at high risk of cardiovascular events. The HOPE study investigators.. Canadian Journal of Cardiology. 12:127-137. 1996
- Prognostic Importance of Myocardial Ischemia Detected by Ambulatory Monitoring Early after Acute Myocardial Infarction. New England Journal of Medicine. 334:65-71. 1996
- Detection of Silent Myocardial Ischemia During Ambulatory Monitoring by Time‐Frequency Power Spectral Analysis. Annals of Noninvasive Electrocardiology. 1:63-69. 1996
- Regional distribution and kinetics of [18F]6-flurodopamine as a measure of cardiac sympathetic activity in humans.. Heart. 75:29-34. 1996
- Collaborative cardiovascular clinical trials in Canada. The Canadian Cardiovascular Collaboration.. Canadian Journal of Cardiology. 11:649-657. 1995
- TREATMENT OF MYOCARDIAL-INFARCTION PATIENTS - CONSENSUS REPORT - REVISION OF THE SCC GUIDELINES FORMULATED IN 1991. Canadian Journal of Cardiology. 11:659-669. 1995
- [Treatment of patients with myocardial infarct: consensus report-- revision of the 1991 guidelines issued by the Canadian Society of Cardiology].. Canadian Journal of Cardiology. 11:659-669. 1995
- Evaluation of the reproducibility and accuracy of apex beat measurement in the detection of echocardiographic left ventricular dilation.. Canadian Journal of Cardiology. 11:493-497. 1995
- Management of the postmyocardial infarction patient: a consensus report--revision of 1991 CCS guidelines.. Canadian Journal of Cardiology. 11:477-486. 1995
- The consensus report: is it ever the last word?. Canadian Journal of Cardiology. 11:471. 1995
- Redistribution of Myocardial Blood Flow With Topical Nitroglycerin in Patients With Coronary Artery Disease. Circulation. 91:1381-1388. 1995
- Neurocardiac Responses to Acute Coronary Balloon Occlusion in Humans. Journal of Interventional Cardiology. 7:251-259. 1994
- Heart rate and athletic training. Cardioscience. 28:284-285. 1994
- Operation Everest II: An indication of deterministic chaos in human heart rate variability at simulated extreme altitude. Biological Cybernetics. 69:205-212. 1993
- Predictability of normal heart rhythms and deterministic chaos. Chaos. 3:267-276. 1993
- Power spectral analysis of heart rate variability: a noninvasive signature of cardiac autonomic function.. Critical Reviews in Biomedical Engineering. 21:245-311. 1993
- Neurocardiac Responses to Vagoafferent Electrostimulation in Humans. PACE - Pacing and Clinical Electrophysiology. 15:1581-1587. 1992
- Neural regulation of heart rate variability in endurance athletes and sedentary controls. Cardioscience. 26:713-719. 1992
- Effect of Vagal Nerve Electrostimulation on the Power Spectrum of Heart Rate Variability in Man. PACE - Pacing and Clinical Electrophysiology. 15:235-243. 1992
- Diurnal variations of neurocardiac rhythms in acute myocardial infarction. American Journal of Cardiology. 68:155-160. 1991
- Report of the Canadian Cardiovascular Society's consensus conference on the Management of the Postmyocardial Infarction Patient.. CANADIAN MEDICAL ASSOCIATION JOURNAL. 144:1015-1025. 1991
- Effects of steady state exercise on the power spectrum of heart rate variability. Medicine & Science in Sports & Exercise. 23:428???434-428???434. 1991
- Development and testing of a new measure of health status for clinical trials in heart failure. Journal of General Internal Medicine. 4:101-107. 1989
- Power spectrum of heart rate variability: a non-invasive test of integrated neurocardiac function.. Clinical and Investigative Medicine. 11:331-340. 1988
- Spectral analysis of heart rate variability following human heart transplantation: evidence for functional reinnervation. Autonomic Neuroscience: Basic and Clinical. 23:199-206. 1988
- A controlled trial of digoxin in congestive heart failure. American Journal of Cardiology. 61:371-375. 1988
- Microcomputerized on-line evaluation of heart rate variability power spectra in humans. Computers in Biology and Medicine. 18:165-171. 1988
- Intrinsic indices of the left ventricle as a blood pump in normal and infarcted left ventricles. Medical Engineering and Physics. 9:206-215. 1987
- Heart rate variability power spectrogram as a potential noninvasive signature of cardiac regulatory system response, mechanisms, and disorders. Heart and Vessels. 3:33-41. 1987
- The effect of afterload on the cardiodepressor reflex response to coronary artery occlusion in dogs. Canadian Journal of Physiology and Pharmacology. 63:1560-1564. 1985
- Isoxsuprine and Pulmonary Edema. Chest. 88:643-644. 1985
- The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure.. CANADIAN MEDICAL ASSOCIATION JOURNAL. 132:919-923. 1985
- Effect of encouragement on walking test performance.. Thorax. 39:818-822. 1984
- Pulmonary edema associated with isoxsuprine therapy. American Journal of Obstetrics and Gynecology. 148:625-629. 1984
- ECHOCARDIOGRAPHIC ESTIMATES OF PULMONARY-ARTERY WEDGE PRESSURE. New England Journal of Medicine. 307:188-188. 1982
- Mitral valve prolapse or, what to ignore in cardiology.. Canadian Family Physician. 27:631-634. 1981
- Pulmonary veno-occlusive disease: antemortem diagnosis from roentgenographic and hemodynamic findings.. CANADIAN MEDICAL ASSOCIATION JOURNAL. 120:1519-1522. 1979
- Afterload as a predeterminant of haemodynamics and segmental wall motion following coronary artery occlusion. Cardioscience. 13:127-135. 1979
- Myocardial infarction size from serial CPK: variability of CPK serum entry ratio with size and model of infarction.. Circulation. 58:1143-1153. 1978
- Relief of coronary artery spasm by nitroglycerin: Time‐dependent variability in drug action. Catheterization and Cardiovascular Interventions. 4:237-247. 1978
- Differences between the effects of practolol and propranolol on the diastolic properties of the left ventricle. Clinical Pharmacology and Therapeutics. 21:267-271. 1977
- Experience with bretylium tosylate by a hospital cardiac arrest team.. Circulation. 55:541-544. 1977
- Pheochromocytoma presenting with pulmonary edema and hyperamylasemia.. CANADIAN MEDICAL ASSOCIATION JOURNAL. 116:357-359. 1977
- The significance of early changes of positive and negative dp/dt following contrast ventriculography. Catheterization and Cardiovascular Interventions. 2:337-345. 1976
- Letter: Techniques of measuring regional wall motion.. Circulation. 51:395-396. 1975
- Experience with bretylium tosylate by a mobile resuscitation team. Circulation. 52. 1975
- Restoration of Regional Wall Motion by Nitroglycerin Therapy in Patients with Left Ventricular Asynergy. Chest. 66:545-548. 1974
- Response of the left ventricle to nitroglycerin in patients with and without mitral regurgitation.. Heart. 36:357-361. 1974
- Regional Left Ventricular Performance. Circulation. 47:1400-1400. 1973
- Studies on amino acid levels and transport in the mechanically stressed rat heart. Journal of Molecular and Cellular Cardiology. 5:221-233. 1973
- Regional contraction patterns in the normal and ischemic left ventricle in man. American Journal of Cardiology. 31:484-489. 1973
- Time Dependence of Myocardial Contractility in the Human Left Ventricle. Cardioscience. 2:319-328. 1968
- Mechanisms of Angina in Aortic Stenosis. Circulation. 36:480-488. 1967
- Apparatus for study of ventricular function and metabolism in the isolated perfused rat heart.. Journal of applied physiology. 22:836-839. 1967