selected scholarly activity
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conferences
- Activation of the F-F bond by aHF during regio- and stereo-specific fluorinations using [F-18]F-2. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2014
- Anhydrous hydrogen fluoride (aHF): An efficient, but rarely used, solvent for the synthesis of F-18-PET tracers using [F-18]F-2. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2012
- RADIOFLUORINATION OF L-THREO-3-(3,4-DIHYDROXYPHENYL)SERINE: SYNTHESIS OF POTENTIAL F-18 LABELLED PET TRACERS FOR NOREPINEPHRINE. Journal of Labelled Compounds and Radiopharmaceuticals. S195-S195. 2009
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Reactivity and Selectivity of F2 Toward 3,4,6-Tri-O-acetyl-
D -Glucal in Anhydrous HF: Synthesis of [18F]2-Fluoro-2-deoxy-β-D -allose and Its Use for the Detection of a Breast Tumor. ACS Symposium Series. 211-235. 2009 - TEMPERATURE EFFECT ON THE STEREOSPECIFICITY OF NUCLEOPHILIC FLUORINATION: FORMATION OF [18F]TRANS-4-FLUORO-L-PROLINE DURING THE SYNTHESIS OF [18F]CIS-4-FLUORO-L-PROLINE. Journal of Labelled Compounds and Radiopharmaceuticals. S206-S206. 2009
- FLUO 19-Reactivity and selectivity of F2 towards 3,4,6-tri-O-acetyl-D-glucal in anhydrous HF: Synthesis of [18F]-2-fluoro-2-deoxy-ss-D-allose ([18F]2-FD ss A) for the detection of breast tumor. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2006
- Application of fluorine-18 in the syntheses of PET radiotracers. 26th Annual Canadian Nuclear Society Conference and 29th CNS/CNA Student Conference. 687. 2005
- A NEW STRATEGY FOR LABELING BIOMOLECULES THAT CONTAIN DISULFIDE BONDS WITH RHENIUM AND TECHNETIUM. Journal of Labelled Compounds and Radiopharmaceuticals. S50-S50. 2005
- FLUORINE-18 LABELLED AROMATIC AMINO ACIDS FOR TUMOR IMAGING USING PET. Journal of Labelled Compounds and Radiopharmaceuticals. S216-S216. 2005
- REGIO- AND STEREOSELECTIVE ELECTROPHILIC FLUORINATION OF 3,4,6-TRI-O-ACETYL-D-GLUCAL (TAG) IN ACIDIC MEDIUM. Journal of Labelled Compounds and Radiopharmaceuticals. S202-S202. 2005
- Fluoroaryl radiotracers: Effect of aromatic fluorine substitution on in vivo distribution and metabolism.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U650-U650. 2004
- A convenient and robust strategy for radiolabeling polypeptides and proteins for PET and SPECT studies. Diabetes. A440-A440. 2003
- The effect of single-dose risperidone on aromatic amino acid decar☐ylase activity in healthy human subjects measured using [18F]6-fluoro-L-M-tyrosine positron emission tomography. Schizophrenia Research. 243-243. 2003
- The effect of aromatic fluorine substitution in l-DOPA on the in vivo behaviour of []2-, []5- and []6-fluoro-l-DOPA in the human brain. Journal of Fluorine Chemistry. 33-39. 2002
- Improved synthesis, purification and characterization of (18)F3-fluoro-L-alpha-methyl-tyrosine.. Journal of Nuclear Medicine. 256P-257P. 2001
- The effect of N-2 and CO2 on the radiochemical yield and reactivity of [F-18]F-2 produced using O-18(P,N)F-18 gas targets.. Journal of Nuclear Medicine. 246P-246P. 2000
- Initial clinical experience with 18F-fluoro-M-tyrosine positron emission tomography for the investigation of movement disorders. Radiology. 465-465. 1999
- Electrophilic F-18 from O-18(p,n)F-18 target: Adverse effect of oxygen and oxygen difluoride on the direct fluorination of aromatic amino acids.. Journal of Nuclear Medicine. 150P-150P. 1999
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Reactivity and radiochemical yield of [18F]F
2 from 18O(p,n)18F target: 'SINGLE-SHOOT' vs 'DOUBLE-SHOOT' method for the production of [18F]F2 . Journal of Labelled Compounds and Radiopharmaceuticals. 1999 - Repeated recovery, distillation and reuse of oxygen-18 water in 18O(p,n)18F high pressure target. Journal of Labelled Compounds and Radiopharmaceuticals. 1999
- Simultaneous synthesis of 18F-labelled 6-fluoro-m-tyramine and 6-fluoro-3-hydroxy phenylacetic acid: 18F-containing metabolites of [18F]6-fluoro-m-tyrosine. Journal of Labelled Compounds and Radiopharmaceuticals. 1999
- Synthesis of fluorine-18 labelled 5-fluoro-L-DOPA by direct fluorination of L-DOPA. Journal of Labelled Compounds and Radiopharmaceuticals. 1999
- Fluorine-18 as a tracer in positron emission tomography and its application in inorganic and organic synthesis.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U829-U829. 1998
- Clinical experience with the ECAT-ART, an inexpensive positron tomograph. Radiology. 538-538. 1997
- Time dependant changes in myocardial blood flow and sympathetic reinnervation post acute myocardial infarction. Circulation. 3012-3012. 1997
- Radionuclidic contaminants in positron emitting isotopes produced using high-pressure water targets.. Journal of Nuclear Medicine. 420-420. 1997
- The use of [F-18]6-fluoro-L-m-tyrosine in clinical studies of movement disorders.. Journal of Nuclear Medicine. 1153-1153. 1997
- New PET tracers for cerebral dopamine: Should 6-[F-18]fluoro-L-dopa be replaced?. CHEMISTS' VIEWS OF IMAGING CENTERS. 237-247. 1995
- Routine Production of [18F]F2 from 11 MeV Proton-Only Cyclotron and Its Use for the Synthesis of 18F-Tracers for Heart and Brain. CHEMISTS' VIEWS OF IMAGING CENTERS. 425-429. 1995
- MAPPING OF CEREBRAL RESPONSE TO VAGAL AND ESOPHAGEAL STIMULATION USING POSITRON EMISSION TOMOGRAPHY (PET) AND TOPOGRAPHIC EEG IN HUMANS. Gastroenterology. A846-A846. 1994
- NEW PET TRACERS FOR CEREBRAL DOPAMINE - SHOULD 6-[F-18]FLUORO-L-DOPA BE REPLACED. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 73-NUCL. 1993
- ROUTINE PRODUCTION OF [F-18] F2 FROM 11 MEV PROTON-ONLY CYCLOTRON AND ITS USE FOR THE SYNTHESIS OF F-18 TRACERS FOR HEART AND BRAIN. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 135-NUCL. 1993
- REGIONAL DISTRIBUTION AND WASHOUT OF 6-[F-18] FLUORODOPAMINE AS A MEASURE OF CARDIAC SYMPATHETIC ACTIVITY IN MAN. Circulation. 247-247. 1992
- Do the metabolites of 6-[F-18]fluoro-L-dopa and of [F-18]fluoro-meta-L-tyrosine contribute to the F-18 accumulation in the human brain?. Journal of Labelled Compounds and Radiopharmaceuticals. 1991
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The sequential production of [18F]-6-FDOPA and [18F]-F-m-tyrosine (or [18F]-2-FDG) from the same dilute [18F]F
2 target gas. Journal of Labelled Compounds and Radiopharmaceuticals. 1991 - [F-18]Fluoro-meta-L-tyrosine is a better PET tracer than [F-18]fluoro-L-dopa for the deliniation of dopaminergic structures in the human brain. Journal of Labelled Compounds and Radiopharmaceuticals. 1991
- DIRECT FLUORINATION WITH F-18 LABELED FLUORINE-GAS IN HYDROGEN-FLUORIDE. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 14-NUCL. 1989
- A CONCOMITANT LOSS OF MOTOR FUNCTION AND STRIATAL DOPAMINE IN PARKINSONS-DISEASE. Archives of Neurology. 809-809. 1988
- ELECTROPHILIC RADIOFLUORINATION OF AROMATIC-AMINO-ACIDS. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 37-FLUO. 1988
- PARKINSONS-DISEASE - A FRESH LOOK THROUGH 6[F-18]FLUORO-L-DOPA. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 38-FLUO. 1988
- 2-[F-18] FLUORO-L-DOPA. Journal of Labelled Compounds and Radiopharmaceuticals. 1103-1103. 1986
- AROMATIC RADIOFLUORINATION WITH [F-18] F2 IN ANHYDROUS HYDROGEN-FLUORIDE. Journal of Labelled Compounds and Radiopharmaceuticals. 1106-1108. 1986
- DIRECT FLUORINATION OF MELATONIN AND 5-HYDROXY-L-TRYPTOPHAN WITH [F-18] F2. Journal of Labelled Compounds and Radiopharmaceuticals. 1101-1102. 1986
- F-18 LABELED XENON DIFLUORIDE. Journal of Labelled Compounds and Radiopharmaceuticals. 1342-1342. 1982
- MEASUREMENT OF CEREBRAL DOPAMINE METABOLISM - DESIGN AND SYNTHESES OF A POSITRON EMITTING DOPA. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 42-NUCL. 1981
- RADIOFLUORINATION WITH XENON DIFLUORIDE - L-6[F-18]FLUORO-DOPA. Journal of Labelled Compounds and Radiopharmaceuticals. 7-8. 1981
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journal articles
- PET/CT using 18F-FDOPA provides improved staging of carcinoid tumor patients in a Canadian setting. Nuclear Medicine Communications. 33:322-330. 2012
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Temperature effects on the stereospecificity of nucleophilic fluorination: formation of trans‐[18F]4‐fluoro‐
l ‐proline during the synthesis of cis‐[18F]4‐fluoro‐l ‐proline. Journal of Labelled Compounds and Radiopharmaceuticals. 55:23-28. 2012 - NMR Spectroscopic Evidence for the Intermediacy of XeF3− in XeF2/F− Exchange, Attempted Syntheses and Thermochemistry of XeF3− Salts, and Theoretical Studies of the XeF3− Anion. Inorganic Chemistry. 49:8997-9004. 2010
- 6-l-18F-Fluorodihydroxyphenylalanine PET in Neuroendocrine Tumors: Basic Aspects and Emerging Clinical Applications. Journal of Nuclear Medicine. 49:573-586. 2008
- Selective fluorination of m-tyrosine by OF2. Journal of Fluorine Chemistry. 129:22-27. 2008
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Trifluoromethanesulfonic acid, an alternative solvent medium for the direct electrophilic fluorination of DOPA: new syntheses of 6‐[18F]fluoro‐
L ‐DOPA and 6‐[18F]fluoro‐D ‐DOPA. Journal of Labelled Compounds and Radiopharmaceuticals. 50:1236-1242. 2007 - Two-step regio- and stereoselective syntheses of [19F]- and [18F]-2-deoxy-2-(R)-fluoro-β-d-allose. Carbohydrate Research. 341:457-466. 2006
- Synthesis and in Vitro Evaluation of18F- and19F-Labeled Insulin: A New Radiotracer for PET-based Molecular Imaging Studies. Journal of Medicinal Chemistry. 49:1466-1474. 2006
- Effect of acute antipsychotic administration on dopamine synthesis in rodents and human subjects using 6‐[18F]‐L‐m‐tyrosine. Synapse. 52:153-162. 2004
- Syntheses of [18F]5-fluoro-3-nitro-l-tyrosine. Journal of Fluorine Chemistry. 121:9-14. 2003
- On The Preparation of Fluorine-18 Labelled XeF2 and Chemical Exchange between Fluoride Ion and XeF2. Journal of the American Chemical Society. 124:12863-12868. 2002
- Selectivity of elemental fluorine towards l-tyrosine and l-α-methyltyrosine in acidic media and the syntheses of their []3-fluoro and []3,5-difluoro derivatives. Journal of Fluorine Chemistry. 111:17-25. 2001
- Equilibration of 6-[18F]fluoro-L-m-tyrosine between plasma and erythrocytes.. Journal of Nuclear Medicine. 41:1636-1641. 2000
- The time course of metabolites in human plasma after 6-[ 18 F]fluoro- l - m -tyrosine administration. European Journal of Nuclear Medicine and Molecular Imaging. 26:1407-1412. 1999
- Radiochemical and NMR spectroscopic investigation of the solvent effect on the electrophilic elemental fluorination of L-DOPA: synthesis of []5-fluoro-L-DOPA. Journal of Fluorine Chemistry. 99:87-94. 1999
- Recovery rates of regional sympathetic reinnervation and myocardial blood flow after acute myocardial infarction. American Heart Journal. 137:863-869. 1999
- Enzymatic synthesis of (−)-6-[18F]-fluoronorepinephrine from 6-[18F]-fluorodopamine by dopamine β-hydroxylase. Journal of Labelled Compounds and Radiopharmaceuticals. 41:503-521. 1998
- Direct radiofluorination of dopamine: 18F-labeled 6-fluorodopamine for imaging cardiac sympathetic innervation in humans using positron emission tomography. Nuclear Medicine and Biology. 23:41-45. 1996
- Regional distribution and kinetics of [18F]6-flurodopamine as a measure of cardiac sympathetic activity in humans.. Heart. 75:29-34. 1996
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A probe for intracerebral aromatic amino‐acid decarboxylase activity: Distribution and kinetics of [18F]6‐fluoro‐
L ‐m‐tyrosine in the human brain. Movement Disorders. 10:298-304. 1995 - Base-mediated decomposition of a Mannose triflate during the synthesis of 2-deoxy-2-18F-fluoro-d-glucose. Applied Radiation and Isotopes. 46:149-155. 1995
- Electrophilic 18F from a siemens 11 MeV proton-only cyclotron. Nuclear Medicine and Biology. 22:111-116. 1995
- The Distribution and Kinetics of [18F]6-Fluoro-3-O-Methyl-l-Dopa in the Human Brain. Cerebrovascular and Brain Metabolism Reviews. 14:664-670. 1994
- 18F and the dopamine pathway. Chemistry in Britain. 27. 1991
- F-18 AND THE DOPAMINE PATHWAY. Chemistry in Britain. 27:47-&. 1991
- Synthesis of 18F labelled fluoro-m-tyrosine, fluoro-m-tyramine and fluoro-3-hydroxyphenylacetic acid. Applied Radiation and Isotopes. 42:113-119. 1991
- The hexafluorochlorate(V) anion, ClF6-. Inorganic Chemistry. 29:3506-3511. 1990
- New 18F tracers for the investigation of brain functions.. Acta Radiologica, Supplement. 374:37-41. 1990
- Metabolites of 6-[18F]fluoro-L-dopa in human blood.. Journal of Nuclear Medicine. 29:363-369. 1988
- On the existence of pentacoordinated nitrogen. Inorganic Chemistry. 27:789-790. 1988
- Sequential production of electrophilic and nucleophilic fluorinating agents from [18F]fluorine gas. Applied Radiation and Isotopes. 39:1099-1101. 1988
- Synthesis of f‐18 labelled fluoro‐melatonins and 5‐hydroxy‐fluoro‐tryptophans. Journal of Labelled Compounds and Radiopharmaceuticals. 25:63-71. 1988
- Synthesis of 2- and 3-fluorotyrosine with dilute fluorine gas. Journal of Fluorine Chemistry. 37:267-278. 1987
- A ROSTROCAUDAL GRADIENT FOR AROMATIC ACID DECARBOXYLASE IN THE HUMAN STRIATUM. Canadian Journal of Neurological Sciences. 14:444-447. 1987
- A Rostrocaudal Gradient for Aromatic Acid Decarboxylase in the Human Striatum. Canadian Journal of Neurological Sciences. 14:444-447. 1987
- Cerebral Metabolism of 6–[18F]Fluoro‐l‐3,4‐Dihydroxyphenylalanine in the Primate. Journal of Neurochemistry. 48:1077-1082. 1987
- Determination and visualization of damage to striatal dopaminergic terminals in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism by [18F]-labeled 6-fluoro-L-dopa and positron emission tomography.. Advances in neurology. 45:167-169. 1987
- High yield synthesis of 6-[18F]fluoro-L-dopa.. Journal of Nuclear Medicine. 27:417-421. 1986
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Direct fluorination of melatonin and 5-hydroxy-L-tryptophan with [18F]F
2 . Journal of Labelled Compounds and Radiopharmaceuticals. 23:1101-1102. 1986 - [18F]Fluoro-l-dopa for the in vivo study of intracerebral dopamine. Applied Radiation and Isotopes. 37:669-675. 1986
- [F-18] FLUORO-L-DOPA FOR THE INVIVO STUDY OF INTRACEREBRAL DOPAMINE. Applied Radiation and Isotopes. 37:669-675. 1986
- Aromatic radiofluorination with [18F]fluorine gas: 6-[18F]fluoro-L-dopa.. Journal of Nuclear Medicine. 25:1228-1233. 1984
- Radiofluorination with 18F-labelled acetyl hypofluorite: [18F]L-6-fluorodopa. Applied Radiation and Isotopes. 35:651-653. 1984
- The synthesis of [18F]Xenon difluoride from [18F]fluoride gas. Applied Radiation and Isotopes. 35:401-404. 1984
- Striatal dopamine metabolism in living monkeys examined by positron emission tomography. Brain Research. 280:169-171. 1983
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Synthesis of [18F]XeF
2 , a novel agent for the preparation of 18F-radiopharmaceuticals. Journal of the Chemical Society - Series Chemical Communications. 198-199. 1981 - SYNTHESIS OF [F-18]XEF2, A NOVEL AGENT FOR THE PREPARATION OF F-18-RADIOPHARMACEUTICALS. Journal of the Chemical Society - Series Chemical Communications. 198-199. 1981
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Aromatic fluorination with xenon difluoride:
L -3,4-dihydroxy-6-fluoro-phenylalanine. Canadian Journal of Chemistry. 58:1449-1450. 1980