selected scholarly activity
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conferences
- Clinical safety and efficacy of 90yttrium resin microspheres alone in unresectable, heavily pre-treated colorectal liver metastases: results of a phase II trial. Journal of Clinical Oncology. 4078-4078. 2008
- Telomere length polymorphisms and their impact on tumor karyotype evolution. Chromosome Research. 49-49. 2007
- Telomerase triggers angiogenesis and is required for VEGF responsiveness in hind-limb ischemia. Circulation. 173-173. 2004
- Epiadryamicin concentration in experimental hepatic metastases after bolus or continous infusion through systemic or locoregional routes. Journal of Experimental and Clinical Cancer Research. 229-232. 2003
- Epirubicin and its metabolites levels in experimental liver metastases after different administration routes.. Journal of Experimental and Clinical Cancer Research. 181-185. 2003
- Natural history of the neoplastic locoregional disease: Clinical and pathological patterns. Journal of Experimental and Clinical Cancer Research. 1-4. 2003
- Genetic control of telomerase and replicative senescence in human and rodent cells - Discussion. Ciba Foundation symposium. 189-197. 1998
- Human ageing and telomeres - Discussion. Ciba Foundation symposium. 139-144. 1998
- Mouse models for the study of telomerase - Discussion. Ciba Foundation symposium. 170-176. 1998
- Telomerase assays in the diagnosis and prognosis of cancer - Discussion. Ciba Foundation symposium. 155-159. 1998
- Telomeres in the haemopoietic system - Discussion. Ciba Foundation symposium. 219-222. 1998
- LACK OF TELOMERASE IN HUMAN NORMAL DIPLOID EPITHELIAL-CELL LINES WITH UNLIMITED LIFE-SPAN IN-VITRO. Molecular Biology of the Cell. 72-72. 1995
- TELOMERE LENGTH AND TELOMERASE ACTIVITY IN HEMATOLOGIC MALIGNANCIES. Blood. A38-A38. 1994
- TELOMERES AND TELOMERASE - BIOCHEMISTRY AND REGULATION IN SENESCENCE AND IMMORTALIZATION. CHROMOSOME. 115-125. 1993
- INDUCTION OF FRAGILE SITES BY APHIDICOLIN AND METHOTREXATE IN HUMAN EMBRYONIC-CELLS. American Journal of Human Genetics. 282-282. 1991
- CONTROL OF HERPES-SIMPLEX VIRUS THYMIDINE KINASE TRANSCRIPTION. European Journal of Cell Biology. 40-40. 1980
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journal articles
- The senescent microenvironment promotes the emergence of heterogeneous cancer stem-like cells. Carcinogenesis. 36:1180-1192. 2015
- Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas. Carcinogenesis. 34:1173-1180. 2013
- The heterochromatic chromosome caps in great apes impact telomere metabolism. Nucleic Acids Research (NAR). 41:4792-4801. 2013
- Estrogen-Dependent Dynamic Profile of eNOS-DNA Associations in Prostate Cancer. PLoS ONE. 8:e62522-e62522. 2013
- Molecular imaging of nuclear factor-Y transcriptional activity maps proliferation sites in live animals. Molecular Biology of the Cell. 23:1467-1474. 2012
- Silencing of GSTP1, a Prostate Cancer Prognostic Gene, by the Estrogen Receptor-β and Endothelial Nitric Oxide Synthase Complex. Molecular Endocrinology. 25:2003-2016. 2011
- The role of nuclear endothelial nitric oxide synthase in the endothelial and prostate microenvironments. Hormone Molecular Biology and Clinical Investigation. 5:91-96. 2011
- Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination. Proceedings of the National Academy of Sciences of the United States of America. 106:15726-15731. 2009
- Endothelial NOS, estrogen receptor β, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer. Journal of Clinical Investigation. 119:1093-1108. 2009
- The telomerase tale in vascular aging: regulation by estrogens and nitric oxide signaling. Journal of applied physiology. 106:333-337. 2009
- Estrogen Receptor-α and Endothelial Nitric Oxide Synthase Nuclear Complex Regulates Transcription of Human Telomerase. Circulation Research. 103:34-42. 2008
- Epithelial-Restricted Gene Profile of Primary Cultures from Human Prostate Tumors: A Molecular Approach to Predict Clinical Behavior of Prostate Cancer. Molecular Cancer Research. 4:79-92. 2006
- A multicentric phase II clinical trial on intra-arterial hepatic radiotherapy with 90yttrium SIR-spheres in unresectable, colorectal liver metastases refractory to i.v. chemotherapy: preliminary results on toxicity and response rates.. In Vivo. 20:711-714. 2006
- A human cell line that maintains telomeres in the absence of telomerase and of key markers of ALT. Oncogene. 24:7893-7901. 2005
- Telomerase Mediates Vascular Endothelial Growth Factor-dependent Responsiveness in a Rat Model of Hind Limb Ischemia. Journal of Biological Chemistry. 280:14790-14798. 2005
- Alternative Lengthening of Telomeres Is Characterized by High Rates of Telomeric Exchange. Cancer Research. 64:2324-2327. 2004
- The shortest telomeres drive karyotype evolution in transformed cells. Oncogene. 23:1221-1228. 2004
- Epiadryamicin concentration in experimental hepatic metastases after bolus or continous infusion through systemic or locoregional routes.. Journal of Experimental and Clinical Cancer Research. 22:229-232. 2003
- Herpes simplex virus type-1 infection upregulates cellular promoters and telomerase activity in both tumor and nontumor human cells. Gene Therapy. 10:1494-1502. 2003
- Cytokine, infiltrating macrophage and T cell-mediated response to development of primary and secondary human liver cancer. Digestive and Liver Disease. 34:794-801. 2002
- Telomere maintenance by telomerase and by recombination can coexist in human cells. Human Molecular Genetics. 10:1945-1952. 2001
- Transient expression of wild type of biologically active telomerase allows the formation of artificial telomeres in mortal human cells (vol 266, 342, 2001). Experimental Cell Research. 267:275-275. 2001
- Transient Expression of Wild-Type or Biologically Inactive Telomerase Allows the Formation of Artificial Telomeres in Mortal Human Cells. Experimental Cell Research. 266:342-342. 2001
- Transient Expression of Wild-Type or Biologically Inactive Telomerase Allows the Formation of Artificial Telomeres in Mortal Human Cells. Experimental Cell Research. 265:304-311. 2001
- Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability. Oncogene. 20:714-725. 2001
- Histone Deacetylation Is Involved in the Transcriptional Repression of hTERT in Normal Human Cells. Journal of Biological Chemistry. 275:35665-35668. 2000
- Induction of hTERT Expression and Telomerase Activity by Estrogens in Human Ovary Epithelium Cells. Molecular and Cellular Biology. 20:3764-3771. 2000
- Construction of a recombinant adenovirus for efficient delivery of the I-Scel yeast endonuclease to human cells and its application in the in vivo cleavage of chromosomes to expose new potential telomeres. Nucleic Acids Research (NAR). 27:4276-4281. 1999
- Genetic interactions between error-prone and error-free postreplication repair pathways in Saccharomyces cerevisiae. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 435:1-11. 1999
- Telomere-dependent senescence. Nature Biotechnology. 17:313-313. 1999
- The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter. Human Molecular Genetics. 8:137-142. 1999
- Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines. Oncogene. 17:1321-1326. 1998
- Reconstitution of Wild-Type or Mutant Telomerase Activity in Telomerase-Negative Immortal Human Cells. Human Molecular Genetics. 7:1137-1141. 1998
- Dissociation of Telomere Dynamics from Telomerase Activity in Human Thyroid Cancer Cells. Experimental Cell Research. 240:333-339. 1998
- Induction of fragility at the human RNU2 locus by cytosine arabinoside is dependent upon a transcriptionally competent U2 small nuclear RNA gene and the expression of p53. Somatic Cell and Molecular Genetics. 23:379-389. 1997
- Reprogramming of Telomerase by Expression of Mutant Telomerase RNA Template in Human Cells Leads to Altered Telomeres That Correlate with Reduced Cell Viability. Molecular and Cellular Biology. 17:6394-6401. 1997
- hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization. Cell. 90:785-795. 1997
- The Telomere Lengthening Mechanism in Telomerase-Negative Immortal Human Cells Does Not Involve the Telomerase RNA Subunit. Human Molecular Genetics. 6:921-926. 1997
- A survey of telomerase activity in human cancer. European Journal of Cancer. 33:787-791. 1997
- Hot papers - Telomere biology - Telomerase activity in normal leukocytes and hematologic malignancies by C.M. Counter, J. Gupta, C.B. Harley, B. Leber, S. Bacchetti - Comments. SCIENTIST. 11:15-15. 1997
- Telomeres in the Haemopoietic System. Novartis Foundation Symposium. 211:209-226. 1997
- Development of Retinoblastoma in the Absence of Telomerase Activity. Journal of the National Cancer Institute. 88:1152-1157. 1996
- Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues.. Cancer Research. 56:645-650. 1996
- Telomere dynamics and telomerase activity in cell senescence and cancer. Seminars in Cell and Developmental Biology. 7:31-39. 1996
- Telomere maintenance in tumour cells.. Cancer Surveys. 28:197-216. 1996
- Telomeres and Telomerase in Normal and Malignant Haematologic Cells. Leukemia and Lymphoma. 24:1-9. 1996
- High frequency recombination betweenloxP sites in human chromosomes mediated by an adenovirus vector expressing Cre recombinase. Somatic Cell and Molecular Genetics. 21:429-441. 1995
- The Transcriptionally Competent U2 Gene Is Necessary and Sufficient for Adenovirus Type 12 Induction of the Fragile Site at 17q21-22. Molecular and Cellular Biology. 15:6256-6261. 1995
- TELOMERE AND TELOMERASE IN HUMAN CANCER (REVIEW) (VOL 7, PG 423, 1995). International Journal of Oncology. 7:941-941. 1995
- Telomerase activity in normal and malignant murine tissues.. Oncogene. 11:893-898. 1995
- TELOMERES AND TELOMERASE IN HUMAN CANCER (REVIEW). International Journal of Oncology. 7:423-432. 1995
- Telomere elongation in immortal human cells without detectable telomerase activity.. EMBO Journal. 14:4240-4248. 1995
- Telomerase activity associated with acquisition of malignancy in human colorectal cancer.. Cancer Research. 55:2533-2536. 1995
- Telomerase activity in normal leukocytes and in hematologic malignancies. Blood. 85:2315-2320. 1995
- Extended abstract: Unlimited life span of human diploid normal epithelial cells. International Journal of Cancer. 3:363-367. 1995
- Induction of genomic instability in SV40 transformed human cells: sufficiency of the N-terminal 147 amino acids of large T antigen and role of pRB and p53.. Oncogene. 9:2943-2950. 1994
- Establishment and characterization of four human epithelial ovarian carcinoma cell lines. Cancer. 74:900-906. 1994
- Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. Journal of Virology. 68:3410-3414. 1994
- Telomerase activity in human ovarian carcinoma.. Proceedings of the National Academy of Sciences of the United States of America. 91:2900-2904. 1994
- Telomerase, Cell Immortality, and Cancer. Cold Spring Harbor Symposia on Quantitative Biology. 59:307-315. 1994
- INHIBITION OF CELL-PROLIFERATION BY AN ADENOVIRUS VECTOR EXPRESSING THE HUMAN WILD TYPE-P53 PROTEIN. International Journal of Oncology. 3:781-788. 1993
- Generation of a new adenovirus type 12-inducible fragile site by insertion of an artificial U2 locus in the human genome.. Molecular and Cellular Biology. 13:6064-6070. 1993
- Quantitative analysis of regions of adenovirus E1A products involved in interactions with cellular proteins. Biochemistry and Cell Biology. 70:1123-1134. 1992
- Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.. EMBO Journal. 11:1921-1929. 1992
- Synergism between aphidicolin and adenoviruses in the induction of breaks at fragile sites on human chromosomes. Cancer genetics. 54:39-53. 1991
- Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells. Virology. 180:49-57. 1991
- Chromosomal damage induced by human adenovirus type 12 requires expression of the E1B 55-kilodalton viral protein. Journal of Virology. 64:2090-2095. 1990
- Definition of adenovirus type 5 functions involved in the induction of chromosomal aberrations in human cells. Journal of General Virology. 71:801-808. 1990
- Cloning of the herpes simplex virus ICP4 Gene in an adenovirus vector: Effects on adenovirus gene expression and replication. Virology. 168:378-387. 1989
- The responsiveness of human papillomavirus upstream regulatory regions to herpes simplex virus immediate early proteins. Virus Research. 11:199-207. 1988
- Expression of the HSV-2 ribonucleotide reductase subunits in adenovirus vectors or stably transformed cells: Restoration of enzymatic activity by reassociation of enzyme subunits in the absence of other HSV proteins. Virology. 163:462-470. 1988
- Oligopeptides inhibit the ribonucleotide reductase of herpes simplex virus by causing subunit separation. Virology. 162:270-273. 1988
- In cell lines constitutively synthesizing a temperature-sensitive ICP4 protein of herpes simplex virus type 1, amount and function of ICP4 are both regulated by temperature. Virology. 158:285-293. 1987
- CORRECTION. Journal of Virology. 58:713-713. 1986
- Identification and separation of the two subunits of the herpes simplex virus ribonucleotide reductase. Journal of Virology. 57:1177-1181. 1986
- Protein kinase and ATP-binding activity associated with the 72-kdalton single-stranded DNA-binding protein from early region 2A of human adenovirus type 5. Biochemistry and Cell Biology. 63:941-952. 1985
- Activation and inhibition of expression of the 72,000-da early protein of adenovirus type 5 in mouse cells constitutively expressing an immediate early protein of herpes simplex virus type 1. Virology. 144:35-45. 1985
- Cells that constitutively express the herpes simplex virus immediate-early protein ICP4 allow efficient activation of viral delayed-early genes in trans. Journal of Virology. 54:414-421. 1985
- An assay for ribonucleotide reductase based on ion-exchange chromatography of the reaction product. Analytical Biochemistry. 145:331-338. 1985
- Herpes simplex virus type 2 and human papillomavirus type 16 in cervicitis, dysplasia and invasive cervical carcinoma. International Journal of Cancer. 35:51-57. 1985
- Immunological characterization of herpes simplex virus type 1 and 2 polypeptide(s) involved in viral ribonucleotide reductase activity. Journal of Virology. 49:591-593. 1984
- Establishment and characterization of hamster cell lines transformed by restriction endonuclease fragments of adenovirus 5. Journal of Virology. 49:162-170. 1984
- Transformation by human adenoviruses. Journal of cellular physiology. Supplement. 121:151-163. 1984
- Herpes Simplex Virus-induced Ribonucleotide Reductase: Development of Antibodies Specific for the Enzyme. Journal of General Virology. 64:1327-1335. 1983
- Is ribonucleotide reductase the transforming function of herpes simplex virus 2?. Nature. 302:76-79. 1983
- Mapping of a 14,000-dalton antigen to early region 4 of the human adenovirus 5 genome. Journal of Virology. 45:514-523. 1983
- Covalently closed circles of adenovirus 5 DNA. Nature. 301:172-174. 1983
- Studies on transformation of mammalian cells by human adenovirus type 5 (Ad5) and Ad5 DNA.. Progress in Clinical and Biological Research. 132C:313-325. 1983
- Glycoproteins of herpes simplex virus type 2 as defined by monoclonal antibodies. Journal of Virology. 44:344-355. 1982
- Protection against lethal challenge of BALB/c mice by passive transfer of monoclonal antibodies to five glycoproteins of herpes simplex virus type 2. Infection and Immunity. 37:1132-1137. 1982
- Tn5 mutagenesis of the transforming genes of human adenovirus type 5. Gene. 19:33-42. 1982
- Integration and expression of viral DNA in cells transformed by host range mutants of adenovirus type 5. Journal of Virology. 41:674-685. 1982
- Monoclonal antibodies to two glycoproteins of herpes simplex virus type 2. Journal of Virology. 39:438-446. 1981
- Production of hybrid cell lines secreting antibodies to herpes simplex virus type 2. Journal of Virological Methods. 2:223-236. 1981
- Partial purification and characterization of the ribonucleotide reductase induced by herpes simplex virus infection of mammalian cells. Journal of Virology. 37:580-588. 1981
- Herpes simplex virus thymidine kinase transcripts are absent from both nucleus and cytoplasm during infection in the presence of cycloheximide. Journal of Virology. 36:361-365. 1980
- A rapid and efficient procedure for the purification of DNA from agarose gels. Analytical Biochemistry. 106:492-496. 1980
- Selective assay for herpes simplex viruses expressing thymidine kinase. Journal of Virology. 31:281-287. 1979
- Characterization of Human TK- Cell Lines Transformed to a TK+ Phenotype by Herpes Simplex Virus Type 2 DNA. Journal of General Virology. 42:149-157. 1979
- DNA-mediated transfer of herpes simplex virus TK gene to human TK- cells: properties of the transformed lines.. IARC (International Agency for Research on Cancer) Scientific Publications. No. 24:495-499. 1978
- Transfer of the gene for thymidine kinase to thymidine kinase-deficient human cells by purified herpes simplex viral DNA.. Proceedings of the National Academy of Sciences of the United States of America. 74:1590-1594. 1977
- Relation of Herpes Simplex Viruses to Human Malignancies. Current Topics in Microbiology and Immunology. 77:71-95. 1977
- THE EFFECT OF IRRADIATION WITH ULTRAVIOLET LIGHT ON THE SEDIMENTATION BEHAVIOUR OF PM2 DNA. Photochemistry and Photobiology. 23:205-208. 1976
- Purification and characterization of an endonuclease from calf thymus acting on irradiated DNA. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 390:285-297. 1975
- Studies on DNA Repair in Mammalian Cells: An Endonuclease Which Recognizes Lesions in DNA. Basic Life Sciences. 5B:651-654. 1975
- Repair Endonucleases. Nature. 240:428-428. 1972
- A UV-specific endonucleolytic activity present in human cell extracts. Biochemical and Biophysical Research Communications. 48:662-669. 1972
- The Effects of X-Rays on the Synthesis of DNA, RNA, and Proteins in Synchronized Chinese Hamster Cells. Radiation Research. 45:598-598. 1971
- The Relation of Protein Synthesis to Radiation-Induced Division Delay in Chinese Hamster Cells. Radiation Research. 44:788-788. 1970
- Automated Continuous Culture of Mammalian Cells in Suspension. Science. 169:204-205. 1970
- Actinomycin D. Biophysical Journal. 9:1427-1445. 1969
- An attempt to grow HeLa cells in an Eisler-Webb nephelostat. ANL-7635.. ANL. 128-129. 1969
- Cycloheximide- and radiation-induced division delay in synchronized Chinese hamster cells. ANL-7635.. ANL. 238-240. 1969
- The effect of x rays on the uptake of 3H-leucine in synchronized Chinese hamster cells. ANL-7635.. ANL. 240-241. 1969
- THE ACTION OF HYDROXYUREA ON MOUSE L‐CELLS*. Cell Proliferation. 2:193-211. 1969