Active Grants for the Health Research Methods, Evidence, and Impact department

Grant Name Close Date
10-year Follow-Up of the South Asian Birth Cohort: Understanding early life determinants of cardiovascular disease 9/30/2026
2/2 Catheter-Directed Therapy for Chronic DVT (C-TRACT Trial)-DCC 8/31/2025
A Clinical Prediction Model for the Diagnosis of Immune Thrombocytopenia 9/30/2025
A Community Based Research Project: Analyzing The Barriers And Facilitators To Healthy Active Living Amongst Newly Immigrated Families With Children 4/30/2025
A Phase 3 Prospective, Randomized, Partially Blinded Multi-Center Study to Measure the Safety and Efficacy of NOVOCART 3D Compared to Microfracture in the Treatment of Articular Cartilage Defects 1/1/2025
A Phase I Qualitative Study to Develop a New Patient-Reported Outcome Instrument for Children with Congenital and Acquired Differences of the Hands and Upper Limb 4/30/2026
A Phase III Non-Inferiority Randomized Controlled Trial (RCT) of Fixed-Duration Daratumumab Versus Continuous Daratumumab Among Transplant Ineligible Older Adults with Newly-Diagnosed Multiple Myeloma 10/31/2031
A ProSpective, MulticEnter, Concurrently Controlled Clinical Study of Chondro-Gide® ArticUlar Cartilage CoveR for the Treatment of Large Chondral Lesions in the KnEe (SECURE) 1/1/2026
A Randomized Trial of Partial Breast Irradiation 9/30/2028
A Randomized Trial of Regional Radiotherapy in Luminal A Breast Cancer 6/30/2025
A Single Dose Antenatal Corticosteroids (SNACS) Non-Inferiority Randomized Control Trial for Pregnancies at Risk of Preterm Delivery 5/31/2029
A Training Platform in Pragmatic Registry-Based Trials: Connecting Canada's Health, Data, and Biomanufacturing Sectors 8/31/2025
A phase 2 trial to evaluate safety and immunogenicity of a next-generation COVID-19 vaccine delivered by inhaled aerosol to humans 8/31/2025
A phase 2 trial to evaluate safety and immunogenicity of a next-generation COVID-19 vaccine delivered by inhaled aerosol to humans 8/31/2025
A pilot randomized controlled trial comparing arthroplasty versus internal fixation for minimally displaced femoral neck fractures 12/31/2024
A pilot randomized controlled trial comparing flap coverage within 72 hours versus standard of care in type IIIB lower extremity open fractures 12/31/2025
A pilot randomized controlled trial comparing flap coverage within 72 hours versus standard of care in type IIIB lower extremity open fractures. 12/31/2025
A pilot randomized controlled trial comparing internal fixation versus nonoperative care of LC1 pelvic fragility fractures using pelvic binder stress radiography. 12/31/2025
A pilot randomized, double-placebo controlled trial of sublingual or oral immunotherapy for tree nut allergy (TRADE) 9/30/2027
Accelerating Clinical Trials (ACT) - Canada 8/31/2025
Accelerating Clinical Trials (ACT) - Canada 8/31/2025
Accelerating Clinical Trials (ACT) in Canada. 3/1/2026
Advancing equity in maternal and perinatal care in Canada: Population-based investigations of racial and ethnic disparities in severe maternal morbidity and severe perinatal morbidity and mortality 3/31/2027
Aldosterone blockade for Health Improvement Evaluation in End-stage kidney disease: Extension 9/30/2027
Amazzi bulamu (weather and wellbeing): Climate change and pathways to the HIV care cascade among youth living with HIV in Central and Eastern Uganda 9/30/2026
An International Multiphase Program of Research to Develop and Implement a Patient-Reported Outcome Measure for Gender-Affirming Treatments (GENDER-Q) 6/30/2026
An innovative technology-based approach to translating clinical practice guidelines of nutrition therapy in primary care: The Cost, Health, and Effectiveness Assessment of the Portfolio diet in Primary care (CHEAPP) program 3/31/2027
An innovative technology-based approach to translating clinical practice guidelines of nutrition therapy in primary care: The Cost, Health, and Effectiveness Assessment of the Portfolio diet in Primary care (CHEAPP) program 3/31/2027
Anticoagulation for stroke prevention in patients with recent episodes of perioperative atrial fibrillation after noncardiac surgery - The ASPIRE-AF study 9/30/2026
Arthroscopic-assisted tibial plateau fixation (AATPF) vs. Open reduction internal fixation (ORIF): A multicenter randomized controlled trial. 8/31/2025
Assessing the utility of a new class of inheritance mediated by a rare variant genetic risk score for chronic disease prediction 4/30/2025
Association of socioeconomic and environmental factors with neonatal and childhood outcomes of preterm neonates <29 weeks' gestation in Canada 3/31/2025
Autologous MatRix-Induced ChondrogenEsis ComPared with Microfracture for Focal ArtIcular CaRtilage Damage of the Hip (REPAIR): A Pilot Randomized Controlled Trial 12/31/2026
Autologous MatRix-Induced ChondrogenEsis ComPared with Microfracture for Focal ArtIcular CaRtilage Damage of the Hip (REPAIR): A Pilot Randomized Controlled Trial 12/31/2026
Autologous MatRix-Induced ChondrogenEsis ComPared with Microfracture for Focal ArtIcular CaRtilage Damage of the Hip (REPAIR): A Pilot Randomized Controlled Trial 12/31/2026
Autologous MatRix-Induced ChondrogenEsis ComPared with Microfracture for Focal ArtIcular CaRtilage Damage of the Hip (REPAIR): A Pilot Randomized Controlled Trial 12/31/2026
Avoiding Diabetes After Pregnancy Together with Moms (ADAPT-M): Bridging care between the third and fourth trimester 3/31/2028
Bariatric surgery for the Reduction of cArdioVascular Events randomized controlled (BRAVE) trial: vanguard phase for assessment of feasibility 9/30/2025
Building system capacity for home visits for patients near the end of life: A mixed methods study 3/31/2026
CANada in the INCremental dialysis to improve Health outcomes in people starting Hemodialysis (CAN INCH-HD) study: a randomized controlled trial 3/31/2027
CLEAR trial: A 2 x 2 factorial randomized trial of CoLchicine and spironolactonE in patients with myocARdial infarction. 3/31/2026
COLchicine in Ischemic Heart Failure (COL-IHF) 3/31/2027
COMPLETE-2: A prospective, randomized, multi-centre trial of physiology-guided versus angiography-guided complete revascularization to treat multivessel disease after early percutaneous coronary intervention for ST-segment elevation myocardial infarction. 9/30/2025
Canada Reseach Chair - Tier 1 12/31/2028
Canada Reseach Chair - Tier 1 12/31/2028
Canada Research Chair - Tier 1 3/31/2025
Canada Research Chair - Tier 2 1/31/2025
Canada Research Chair - Tier 2 1/31/2025
Canada Research Chair - Tier 2 3/31/2026
Canada Research Chair - Tier 2 3/31/2026
Canada Research Chair - Tier 2 3/31/2027
Canada Research Chairs - Tier 2 8/31/2025
Canadian Alliance of Healthy Hearts and Minds: Dissecting the Pathways Linking Ectopic Adipose Tissue to Cognitive Dysfunction 9/30/2028
Canadian Heart Failure Transformation Alliance: A Network of Likeminded Canadians Committed to Improving the Lives of Persons Living with Heart Failure (HF) 4/30/2027
Canadian Longitudinal Study on Aging 3/31/2027
Canadian Network for Statistical Training in Trials (CANSTAT) 8/31/2025
Canadian Network for Statistical Training in Trials (CANSTAT) 8/31/2025
Canadian emergency department-oriented pulmonary embolism testing (the CED-OPET study) 9/30/2027
Chronic Pain Network: Moving towards knowledge mobilization and implementation science 3/31/2026
Cognitive Behavioural Therapy to Optimize Post-Operative Recovery: A Randomized Controlled Trial (COPE) 1/1/2025
Deriving 24-hour Ambulatory Blood Pressure Monitoring reference values for SouTh AsiaN Children (ABPM-STANCE) 9/30/2026
Development and testing of the McMaster Cough Severity Questionnaire: a new cough symptom severity instrument for patients with chronic cough 4/30/2025
Development of a Knowledge Translation (KT) Quality Appraisal Instrument 3/31/2026
Early arthroscoPic stabilization veRsus rehabilitatiOn of the shoulder in adolescents with a trauMatic first-time anterior shoulder dislocation ePisode: A Randomized Controlled Trial (PROMPT) 12/31/2025
EnVISION No Pain After Surgery: A Pilot Study of Automated Pain Assessments Following Surgery to Help Prevent Chronic Post-Surgical Pain 4/30/2025
Enhancing a Community of Practice for the Health System Impact Fellowship Program: Advancing Capacity for Sustainable & Patient-Centred Learning Health Systems across Canada 12/31/2024
Establishing evidence-based strategic recommendations for patient-centred health care options for individuals experiencing high use of the emergency department 12/31/2024
Estimating the number of children who experience parental incarceration and describing their health status using linked whole population data for five Canadian provinces: The CHIRP (Children with IncarceRated Parents) Study. 3/31/2025
Ethical issues in cluster randomized trials: using stakeholder and patient engagement to generate guidance for the ethical design and conduct of trials evaluating clinical, health policy, health systems, and public health interventions 9/30/2025
Examining the Impacts of the COVID-19 Pandemic Response on Health and Functioning of Canadian Children and Youth 9/30/2025
Expanding midwifery services in Canada: Improving equitable access to sexual and reproductive healthcare through midwifery contributions 3/31/2026
Exploring the role of extravascular factor IX in hemostasis in hemophilia B 9/30/2028
Extending a digital mobility cohort to understand risk factors and impacts of post-COVID conditions in community-living older adults: the Aging, Infection and Mobility (AIM) project 9/30/2026
FetAS: Fetal Assessment Suite to Facilitate Rapid Fetal MRI Diagnosis using Artificial Intelligence 9/30/2028
Further Refinement and Multi-country Validation of a Preliminary Set of Quality Indicators for Palliative Care 3/31/2025
Getting Fit for Hip or Knee Replacement: The Fit Joints Randomized Controlled Trial of A Multimodal Intervention in Frail Patients with Osteoarthritis 3/31/2025
Guideline for cannabis use in chronic pain 12/31/2024
HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) trial – 2. 11/30/2025
HIP fracture Accelerated surgical TreaTment And Care tracK-2 (HIP ATTACK-2) trial 7/31/2027
HIV-C4 (Cascade & Climate Change Cohort): Identifying mechanistic pathways from climate-related factors to HIV prevention and care outcomes in rural and urban Tanzania 9/30/2026
Health and neurodevelopmental trajectories of children and adolescents born at preterm and term gestation 9/30/2027
IMAGINE (Inflammation, Microbiome, and Alimentation: Gastro-Intestinal and Neuropsychiatric Effects) SPOR Chronic Disease Network - Knowledge Mobilization & Implementation Science Phase 2 3/31/2026
Impact of Chiropractic Care on Opioid Use Among Adults with Chronic Non-Cancer Spinal Pain: A Pilot Cluster Randomized Controlled Trial. 3/31/2026
Implementing Client-Centered Care Coordination to Enhance Equity in the HIV Prevention Impact of PrEP among African, Caribbean and Black Communities in Toronto: A Community-Academic Partnership 8/31/2025
InnoVatiOn for Indigenous-led dementia Care to Enhance Safety (VOICES) 9/30/2027
Intergenerational impacts of diabetes among First Nations mothers and their children 9/30/2025
Intravenous DNase I for the treatment of sepsis: A phase 1 safety and feasibility study in ICU patients 3/31/2025
Intravenous Ketorolac versus Morphine in Children Presenting with Suspected Appendicitis: A Multi-Centre Non-Inferiority Randomized Controlled Trial 9/30/2027
Investigating the Genetic Architecture of Sex Differences 12/31/2025
Kaiso, Triple Negative Breast Cancer and Women of African Ancestry. 9/30/2025
Kidney and blood pressure disease burden and monitoring for chronic kidney disease in childhood cancer survivors 3/31/2026
Long COVID Web: Pan-Canadian Post-COVID Condition Research Network 10/31/2027
Long-term results of the LUMINA prospective cohort study evaluating the risk of local recurrence in low Risk luminal a breast cancer 12/31/2024
Longitudinal effects of cannabis legalization in a community cohort of Canadian adults 9/30/2025
Low INR to Minimize bleeding with mechanical valves trial (LIMIT) 3/31/2027
Low dose ColchicinE in pAtients with peripheral artery DiseasE to address residual vascular Risk (LEADER-PAD): A multinational randomized trial 9/30/2028
Mechanisms of weight loss due to dual GIP GLP-1 receptor agonism with tirzepatide compared to semaglutide 9/30/2028
Mindfulness-Based Interventions for OCD: Efficacy, Mechanisms, and Biological Predictors of Outcome 3/31/2025
Mobilizing Knowledge and Implementing Equitable and Cost-Effective Health and Social Care Services for Persons Living with Diabetes in Canada 3/31/2026
Navigation to enhance post-secondary students' acute mental health care transitions 7/31/2026
Non-invasive ventilation and dexmedetomidine in critically ill adults: An international pragmatic randomized controlled trial (inDEX trial) 8/31/2025
Online Public Health Nurse-Delivered 1-Day Cognitive Behavioural Therapy-Based Workshops for Postpartum Depression 3/31/2025
Ontario SPOR SUPPORT Unit: Ontario's Catalyst for Patient-Oriented Research 3/31/2026
Optimizing Fracture Clinics by Having Social Workers Provide Mental Health Support to Fracture Patients. 1/1/2025
PEITHO-3. Reduced-dose thrombolytic treatment for patients with higher-intermediate risk acute pulmonary embolism. 3/31/2027
PRECEDE: Preconception risk factors and Cardiometabolic health in Early childhood 3/31/2025
Pregnant during the COVID-19 pandemic: A prospective, multi-method study examining the impact of chronic prenatal stress on child outcomes. 9/30/2025
Preventing Vision Loss from Diabetic Retinopathy: Guiding Primary Care Diabetic Retinopathy Screening in Canada Through the Use of Provincial Healthcare Administrative Data 12/31/2026
Prospective Evaluation of Breast-Conserving Surgery Alone in Low Risk Ductal Carcinoma in Situ Defined by a Molecular Expression Assay Combined with Clinico-Pathological Features 9/30/2026
Prospective Evaluation of Sports Activity and the Development of Femoroacetabular Impingement in the Adolescent Hip (PREVIEW) 8/31/2025
Prospective Randomized Evaluation of Emerging Novel Treatments for Infection prophylaxis in Total Joint Replacement (PREVENT-iT): A Pilot Study. 1/1/2025
RYR2-targeted Gene Therapies for Treating Catecholaminergic Polymorphic Ventricular Tachycardia 9/30/2027
Randomized Controlled Trial Comparing Antibiotic Cement Bead Pouch Versus Negative-Pressure Wound Therapy for the Management of Severe Open Tibia Fracture Wounds (BvV). 8/31/2026
Randomized Embedded Multifactorial Adaptive Platform Trial of Community Acquired Pneumonia 8/31/2025
Randomized Embedded Multifactorial Adaptive Platform Trial of Community Acquired Pneumonia 8/31/2025
Reducing inequitable differences in health outcomes in the treatment of Arthritis 9/30/2026
SMILE: Optimising SMarter Inclusive Living Environments for ageing people within their circles of care. 12/31/2024
SPOR National Data Platform 8/31/2025
SQUEEZE Trial Dissemination and Planning Next Steps 5/31/2025
Safety and Efficacy of NOVOCART® 3D in the Treatment of Articular Cartilage Defects following failure on Microfracture (RESCUE) 1/1/2028
Salary Support Award for Dr. Greg Pond 3/31/2025
Scaling up shared decision making for patient-centred care 6/30/2025
Selective neuroimaging for head-injured emergency patients who take anticoagulant medication. 9/30/2026
Short Term Anti-aRrhythmic Therapy for Post-Operative AF in Cardiac Surgery Patients: START-POAF Pilot Trial 3/31/2025
Shoulder Instability Trial comparing Arthroscopic Soft Tissue Repair with Bone Transfer (Latarjet) procedure (STABLE): A Pilot Randomized Controlled Trial 3/31/2025
Sleep, Circadian Rhythms, and Dementia-Related Changes in the Human Brain - An Integrated Physiological, Magnetic Resonance Imaging, Cognitive, and Genomic Study of Adult Ontarians 9/30/2025
Small Steps for Big Changes: Implementing an Evidence-Based Diabetes Prevention Program into Diverse Urban Communities 9/30/2028
Soft-tissue QUadriceps autograft ACL-reconstruction in the Skeletally-immature vs. Hamstrings (SQUASH): A Multi-Centre Pilot Randomized Controlled Trial 12/31/2025
Soft-tissue QUadriceps autograft ACL-reconstruction in the Skeletally-immature vs. Hamstrings (SQUASH): A Multi-Centre Pilot Randomized Controlled Trial 12/31/2025
Stakeholder engagement in health care systematic reviews 9/30/2025
Stormy with a chance of HIV: Climate change, resource scarcity, and pathways to HIV prevention among adolescents and youth in Kenya 3/31/2026
Supporting aging in place with dementia: A population-based analysis of health care use, health outcomes and future burden 9/30/2027
Targeted Therapy with Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Right Ventricular Cardiomyopathy (TARGETED-ARVC) 8/31/2025
Targeted Therapy with Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Right Ventricular Cardiomyopathy (TARGETED-ARVC) 8/31/2025
Targeting immunodominant regions on platelet factor 4 for the diagnosis and treatment of heparin-induced thrombocytopenia 9/30/2025
The "predicting Short-term Adverse cardiovasculaR outcomes in preeclampsiA using BIomarkers" (SARABI) Pilot Study 9/30/2025
The Canadian CABG or PCI in Patients with Ischemic Cardiomyopathy (STICH 3.0) Trial 3/31/2029
The Canadian Collaboration for Complex Care: Innovations for optimal and appropriate care for all 7/31/2025
The Corticosteroid Early and Extended (CORT-E2) Randomized Controlled Trial 8/31/2025
The Corticosteroid Early and Extended (CORT-E2) Randomized Controlled Trial 8/31/2025
The EMBOLDEN trial: Enhancing MoBility in OLDEr adults using commuNity co-design. 12/31/2024
The Effect of Canadian Income Transfer Programs on Health 9/30/2027
The Impact of Treating Postpartum Depression on Infant Emotion Regulation 9/30/2025
The Proximal Femur Resection or Internal Fixation for Metastases (PERFORM) Pilot Randomized Controlled Trial 12/31/2026
The Randomized Embedded Multifactorial Adaptive Platform Trial in Community-Acquired Pneumonia (REMAP-CAP): Enshrining a Global Pandemic Research Response to COVID-19 and Beyond 8/31/2025
The Randomized Embedded Multifactorial Adaptive Platform Trial in Community-Acquired Pneumonia (REMAP-CAP): Enshrining a Global Pandemic Research Response to COVID-19 and Beyond 8/31/2025
The Right Timing to prevent Type 2 Diabetes: Restoring 24-hour substrate rhythmicity to improve glycemic control by timing of lifestyle factors 12/31/2025
The TACtful Trial: A first-in-human multi-centre trial of BCMA specific T-cell antigen coupler infusion, generated from cryopreserved G-CSF-mobilized peripheral blood, in patients with relapsed and refractory multiple myeloma. 9/30/2028
The efficacy of soluble, dietary fibre supplementation for the treatment of paediatric non-alcoholic fatty liver disease (NAFLD). 3/31/2027
The impact of cannabis smoke on respiratory tract viral infections 3/31/2028
The impact of opioid and cannabis use during pregnancy on placental and fetal development 9/30/2027
The influence of Cytomegalovirus infection on cystic fibrosis disease progression 9/30/2025
Therapeutic Plasma Exchange in Septic Shock (PLEXSIS): A Pilot Study 3/31/2026
TransitionED: Co-Designing and Implementing Canadian Practice Guidelines for Transitions for Youth with Eating Disorders 7/31/2026
Understanding the impact of the COVID-19 pandemic on obesity and diabetes among Canadians; a prospective population-based cohort study 9/30/2026
University Scholar 6/30/2026
Urinary Biomarkers of Tobacco Smoke Exposure and Harm: An Exposomics Approach to Understand the Smoking Paradox 3/31/2026
Using a novel method to diagnose the prevalence and health impact of muscle loss in older adults 3/31/2027
Using the Robson classification system to examine maternal and perinatal safety associated with operative delivery options in the second stage of labour 4/30/2026
Validation of a novel biomarker classifier that predicts radiation response following breast-conserving surgery for ductal carcinoma in situ (DCIS) 3/31/2027
Vascular events in patients undergoing same-day noncardiac surgery (VALIANCE) - a prospective cohort and nested biobank study 3/31/2026
iCARE 2.0 -Biopsychosocial risk factors for kidney disease in youth onset type 2 diabetes; Longitudinal evaluation and Pilot study of a novel skills-based mental health intervention 3/31/2026